[(2R,5R)-4-azido-3-hydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [(2R,5R)-4-azido-3-hydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C10H12N7O7P
• 分子量: 373.22
• InChiKey: VSMCSSABENEADJ-LKYYUADZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  170
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Adjuvanting systems and water-free vaccine compositions comprising a polyI:C polynucleotide adjuvant and a lipid-based adjuvant
  申请人：IMMUNOVACCINE TECHNOLOGIES INC.

  公开号：US11160861B2

  公开（公告）日：2021-11-02

  The present disclosure provides adjuvanting systems comprising: (a) a polyI:C polynucleotide adjuvant; (b) a lipid-based adjuvant; (c) an amphipathic compound; and (d) a hydrophobic carrier. Also provided are vaccine compositions that are water-free or substantially free of water, which comprise the same components together with one or more antigens. The disclosure also provides uses for such compositions in inducing an antibody (humoral) and/or cell-mediated immune response and methods for their use in the treatment of a disease, disorder or ailment ameliorated by an antibody and/or cell-mediated immune response.

  本公开提供的佐剂系统包括：(a) 聚 I:C 多核苷酸佐剂；(b) 脂基佐剂；(c) 两性化合物；(d) 疏水性载体。还提供了不含水或基本不含水的疫苗组合物，这些组合物由相同的成分和一种或多种抗原组成。本公开还提供了此类组合物在诱导抗体（体液）和/或细胞介导的免疫反应中的用途，以及将其用于治疗通过抗体和/或细胞介导的免疫反应而改善的疾病、失调或病痛的方法。
• Vaccine compositions comprising an amphipathic compound, a neoantigen and a hydrophobic carrier, and methods of use thereof
  申请人：IMMUNOVACCINE TECHNOLOGIES INC.

  公开号：US11260116B2

  公开（公告）日：2022-03-01

  The present application relates to vaccine compositions comprising an amphipathic compound, a neoantigen and a hydrophobic carrier. Further described are methods and use of the vaccine composition for inducing an antibody immune response and/or a cell-mediated immune response to the neoantigen, as well as methods and uses of the vaccine compositions in the treatment of cancer.

  本申请涉及由两性化合物、新抗原和疏水性载体组成的疫苗组合物。进一步描述了疫苗组合物诱导对新抗原的抗体免疫应答和/或细胞介导免疫应答的方法和用途，以及疫苗组合物治疗癌症的方法和用途。
• COMPOSITIONS COMPRISING LIPOSOMES, AN ANTIGEN, A POLYNUCLEOTIDE AND A CARRIER COMPRISING A CONTINUOUS PHASE OF A HYDROPHOBIC SUBSTANCE
  申请人：ImmunoVaccine Technologies Inc.

  公开号：EP2296696A1

  公开（公告）日：2011-03-23
• ADJUVANTING SYSTEMS AND WATER-FREE VACCINE COMPOSITIONS COMPRISING A POLYI:C POLYNUCLEOTIDE ADJUVANT AND A LIPID-BASED ADJUVANT
  申请人：ImmunoVaccine Technologies Inc.

  公开号：EP3377099A1

  公开（公告）日：2018-09-26
• VACCINE COMPOSITIONS COMPRISING AN AMPHIPATHIC COMPOUND, A NEOANTIGEN AND A HYDROPHOBIC CARRIER, AND METHODS OF USE THEREOF
  申请人：ImmunoVaccine Technologies Inc.

  公开号：EP3452083A1

  公开（公告）日：2019-03-13