2,2-bis(dimethylamino)-3,3-difluoro-2H-pyrane | 195391-62-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 原羧酸衍生物
• 英文名称: 2,2-bis(dimethylamino)-3,3-difluoro-2H-pyrane
• 英文别名: 3,3-difluoro-2-N,2-N,2-N',2-N'-tetramethyl-4H-pyran-2,2-diamine
• CAS: 195391-62-9
• 化学式: C₉H₁₆F₂N₂O
• 分子量: 206.236
• InChiKey: UDQQCEZRKGUFLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,2-bis(dimethylamino)-3,3-difluoro-2H-pyrane 以 盐酸 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 2,2-Difluoro-5-oxo-pentanoic acid dimethylamide
  参考文献：
  名称：

  Diverse Cycloaddition Chemistry Leading to Overall Michael Addition in the Reactions of 1,1-Bis(dimethylamino)-2,2-difluoroethene with α,β-Unsaturated Aldehydes, Ketones, Esters, and Nitriles

  摘要：

  Difluoro ketene aminal 1 undergoes [2 + 4] cycloadditions with alpha,beta-unsaturated aldehydes and ketones and [2 + 2] cycloadditions with alpha,beta-unsaturated esters and nitriles. Both types of adducts can be readily converted, by mild hydrolysis, to the respective Michael addition products.

  DOI：

  10.1021/jo9710487
• 作为产物：
  描述：

  2,2,2-三氟-1-二(二甲氨基)乙烷 在 正丁基锂 作用下， 以 正己烷 为溶剂， 反应 10.08h， 生成 2,2-bis(dimethylamino)-3,3-difluoro-2H-pyrane
  参考文献：
  名称：

  Diverse Cycloaddition Chemistry Leading to Overall Michael Addition in the Reactions of 1,1-Bis(dimethylamino)-2,2-difluoroethene with α,β-Unsaturated Aldehydes, Ketones, Esters, and Nitriles

  摘要：

  Difluoro ketene aminal 1 undergoes [2 + 4] cycloadditions with alpha,beta-unsaturated aldehydes and ketones and [2 + 2] cycloadditions with alpha,beta-unsaturated esters and nitriles. Both types of adducts can be readily converted, by mild hydrolysis, to the respective Michael addition products.

  DOI：

  10.1021/jo9710487

文献信息

• Diverse Cycloaddition Chemistry Leading to Overall Michael Addition in the Reactions of 1,1-Bis(dimethylamino)-2,2-difluoroethene with α,β-Unsaturated Aldehydes, Ketones, Esters, and Nitriles
  作者：Yuelian Xu、William R. Dolbier

  DOI：10.1021/jo9710487

  日期：1997.9.1

  Difluoro ketene aminal 1 undergoes [2 + 4] cycloadditions with alpha,beta-unsaturated aldehydes and ketones and [2 + 2] cycloadditions with alpha,beta-unsaturated esters and nitriles. Both types of adducts can be readily converted, by mild hydrolysis, to the respective Michael addition products.