N-dibenzofuran-3-yl-2-(4-methyl-3-nitrophenoxy)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: N-dibenzofuran-3-yl-2-(4-methyl-3-nitrophenoxy)acetamide
• 化学式: C21H16N2O5
• 分子量: 376.4
• InChiKey: GQIOJSBWUHKBSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  97.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• HNF4-alpha ANTAGONIST AND USE THEREOF
  申请人：NATIONAL CANCER CENTER

  公开号：US20160193238A1

  公开（公告）日：2016-07-07

  Provided is a hepatocyte nuclear factor 4 alpha (HNF4-α) antagonist and a use thereof. The HNF4-α antagonist selected in the present invention was confirmed to specifically bind to the ligand binding domain of HNF4-α, thereby inhibiting the activity of HNF4-α. The HNF4-α antagonist of the present invention can significantly reduce the expression of Wnt5a in a specific manner compared to that of the conventional known HNF4-α antagonists, and can also inhibit the growth of gastric cancer cells. Therefore, the HNF4-α antagonist of the present invention can not only be used as a pharmaceutical composition or a health functional food for preventing and treating cancer but can also be applied to a composition for treating or preventing diseases occurring due to the overexpression of HNF4-α.

  提供了一种肝细胞核因子4α（HNF4-α）拮抗剂及其用途。本发明选择的HNF4-α拮抗剂被确认能够特异性结合到HNF4-α的配体结合域，从而抑制HNF4-α的活性。与传统已知的HNF4-α拮抗剂相比，本发明的HNF4-α拮抗剂可以显著特异性地降低Wnt5a的表达，并且还能抑制胃癌细胞的生长。因此，本发明的HNF4-α拮抗剂不仅可以用作预防和治疗癌症的药物组合物或健康功能性食品，还可以应用于治疗或预防由于HNF4-α过度表达而导致的疾病的组合物。