1-Methyl-4-(4-phenyl-2-thiazolyl)piperazine | 231963-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-Methyl-4-(4-phenyl-2-thiazolyl)piperazine
• 英文别名: 2-(4-methylpiperazin-1-yl)-4-phenyl-1,3-thiazole
• CAS: 231963-95-4
• 化学式: C₁₄H₁₇N₃S
• 分子量: 259.37
• InChiKey: KPPSRBNZVBWQQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  47.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Proline derivatives and use thereof as drugs
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP1930319A1

  公开（公告）日：2008-06-11

  The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

  本发明旨在提供因具有 DPP-IV 抑制作用而具有治疗效果的化合物，并提供令人满意的药物产品。 本发明者发现，在式 (I) 所代表的脯氨酸的 γ 位上引入取代基的衍生物 其中各符号如说明书中所定义，具有强效的 DPP-IV 抑制活性，并通过提高稳定性完成了本发明。
• COMPOSITION FOR DYEING KERATIN FIBRES, COMPRISING AN OXIDATION BASE AND A PARTICULAR HETEROARYL COUPLER
  申请人：L'OREAL

  公开号：EP3142638B1

  公开（公告）日：2020-08-12
• US9993409B2
  申请人：——

  公开号：US9993409B2

  公开（公告）日：2018-06-12
• [EN] COMPOSITION FOR DYEING KERATIN FIBRES, COMPRISING AN OXIDATION BASE AND A PARTICULAR HETEROARYL COUPLER<br/>[FR] COMPOSITION POUR LA TEINTURE DE FIBRES DE KERATINE COMPRENANT UNE BASE D'OXYDATION ET UN COUPLEUR HETEROARYLE PARTICULIER
  申请人：OREAL

  公开号：WO2015173324A1

  公开（公告）日：2015-11-19

  The invention relates to a composition comprising: i) at least one oxidation base, preferably of heterocyclic and/or para-phenylenediamine type; and ii) at least one heteroaryl coupler of formula (I), with R1, R2, R3, A and X as defined in the description. The invention also relates to a process for dyeing keratin fibres using ingredients i) and ii); to a kit comprising ingredients i) and ii); and to the use of ingredient i) combined with ii) for dyeing keratin fibres. The composition of the invention leads to particularly powerful, chromatic and sparingly selective colourings.