N-pentyl-4-[4-[4-(N-pentylcarbamimidoyl)phenyl]piperazin-1-yl]benzamidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-pentyl-4-[4-[4-(N-pentylcarbamimidoyl)phenyl]piperazin-1-yl]benzamidine
• 英文别名: N'-pentyl-4-[4-[4-(N'-pentylcarbamimidoyl)phenyl]piperazin-1-yl]benzenecarboximidamide
• 化学式: C₂₈H₄₂N₆
• 分子量: 462.7
• InChiKey: JJDUNDKQXPJHGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Bisbenzamidines for the Treatment of Pneumonia
  申请人：Walzer Peter D.

  公开号：US20110223238A1

  公开（公告）日：2011-09-15

  A method of combating infectious agents, such as Pneumocystis pneumonia, and a method of treating a subject in need of such treatment is disclosed. The method comprises administering to the subject a bis-benzamidoxime of formula I wherein the linker is a di-substituted cyclic moiety of any ring size and may contain at least one heteroatom; the aromatic group is 1,2-; 1,3-; or 1,4-disubstituted; R is selected from the group consisting of a hydrogen, a linear or branched alkyl group, containing from 1 to 20 carbon atoms; R′ is selected from the group consisting of a hydrogen, a linear or branched alkyl group containing from one to twenty carbon atoms, an aromatic ring, a cycloalkyl group containing three to eight carbon atoms, or a hydroxyl group; alternatively, R and R′ may form a cyclic structure that can be fused to another cyclic system; or a pharmaceutically acceptable salt thereof. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.
• US8912359B2
  申请人：——

  公开号：US8912359B2

  公开（公告）日：2014-12-16