alpha-Galactosylceramide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: alpha-Galactosylceramide
• 英文别名: N-[(3S,4R)-3,4-dihydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]hexacosanamide
• 化学式: C₅₀H₉₉NO₉
• 分子量: 858.3
• InChiKey: VQFKFAKEUMHBLV-VDYNBUGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16
• 重原子数：
  60
• 可旋转键数：
  44
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.98
• 拓扑面积：
  169
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• Nanoparticles for immune stimulation
  申请人：THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

  公开号：US10881720B2

  公开（公告）日：2021-01-05

  The invention relates, in part, to nanoparticles, methods for preparing nanoparticles and methods of administering nanoparticles for immune stimulation. An immune-stimulating nanoparticle of the invention may include, at least in part, a polymer substrate comprising a biodegradable polymer and may include at least one antigen and/or at least one adjuvant.

  本发明部分涉及纳米颗粒、制备纳米颗粒的方法和施用纳米颗粒进行免疫刺激的方法。本发明的免疫刺激纳米粒子可至少部分包括由生物可降解聚合物组成的聚合物基底，并可包括至少一种抗原和/或至少一种佐剂。
• [EN] COMBINATION OF ANTIBODY HAVING FC MUTANT AND EFFECTOR CELL, USE THEREOF AND PREPARATION METHOD THEREFOR<br/>[FR] COMBINAISON D'ANTICORPS PRÉSENTANT UN MUTANT FC ET UNE CELLULE EFFECTRICE, UTILISATION CORRESPONDANTE ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ<br/>[ZH] 具有Fc突变体的抗体与效应细胞的组合、用途和制法
  申请人：SHANGHAI SINOBAY BIOTECHNOLOGY CO LTD

  公开号：WO2020154889A1

  公开（公告）日：2020-08-06

  一种具有Fc突变体的靶向肿瘤抗原的抗体和高效免疫效应细胞的组合，其中，所述Fc突变体具有A330L/I332E突变；所述效应细胞为表达CD16的效应细胞。提供了所述组合在制备抗肿瘤的药物中的用途以及所述组合的制备方法。组合采用NKT细胞为效应细胞，联合具有Fc突变体的靶向肿瘤抗原的抗体，提高了肿瘤靶细胞杀伤活性。
• NANOPARTICLES FOR IMMUNE STIMULATION
  申请人：TRUDEAU INSTITUTE

  公开号：US20170165345A1

  公开（公告）日：2017-06-15

  The invention relates, in part, to nanoparticles, methods for preparing nanoparticles and methods of administering nanoparticles for immune stimulation. An immune-stimulating nanoparticle of the invention may include, at least in part, a polymer substrate comprising a biodegradable polymer and may include at least one antigen and/or at least one adjuvant.
• METHOD FOR TREATING CANCER USING ARTIFICIAL ADJUVANT CELL (aAVC)
  申请人：ASTELLAS PHARMA INC.

  公开号：US20220016239A1

  公开（公告）日：2022-01-20

  [Problem to be Solved] Provided is an effective and safe method for treating or preventing a cancer using aAVC. [Solution] The present invention finds suitable ranges of the dose of α-GalCer loaded on aAVC cell surface, and the amount of α-GalCer loaded on aAVC cell surface in a pharmaceutical composition comprising aAVC, which are preferred in terms of securing effectiveness and safety in the treatment and prevention of a cancer using aAVC, and provides an effective and safe method for treating or preventing a cancer using aAVC, aAVC for effective and safe treatment or prevention of a cancer, and a pharmaceutical composition comprising the same, etc.
• [EN] NANOPARTICLES FOR IMMUNE STIMULATION<br/>[FR] NANOPARTICULES POUR STIMULATION IMMUNITAIRE
  申请人：TRUDEAU INST

  公开号：WO2015116775A1

  公开（公告）日：2015-08-06

  The invention relates, in part, to nanoparticles, methods for preparing nanoparticles and methods of administering nanoparticles for immune stimulation. An immune-stimulating nanoparticle of the invention may include, at least in part, a polymer substrate comprising a biodegradable polymer and may include at least one antigen and/or at least one adjuvant.