(5,7-dichloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydro-1H-imidazol-2-yl)-amine | 51322-89-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻二唑类
• 英文名称: (5,7-dichloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydro-1H-imidazol-2-yl)-amine
• 英文别名: 2,1,3-Benzothiadiazol-4-amine, 5,7-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)-；5,7-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
• CAS: 51322-89-5
• 化学式: C₉H₇Cl₂N₅S
• mdl: MFCD27505778
• 分子量: 288.16
• InChiKey: CYEMNKXJFGQDDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  90.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Organic compounds
  申请人：Crawley Edward Patrick

  公开号：US20060063813A1

  公开（公告）日：2006-03-23

  A pharmaceutical composition for treatment of pain, comprises in combination a benzothiadiazole derivative as defined and a COX-2 inhibitor for simultaneous, sequential or separate use. Also provided is a method of treating a patient suffering from pain, comprising administering to the patient an effective amount of a benzothiadiazole derivative as defined and an effective amount of a COX-2 inhibitor.

  一种用于治疗疼痛的药物组合物，由所定义的苯并噻二唑衍生物和 COX-2 抑制剂组合而成，可同时、连续或单独使用。还提供了一种治疗疼痛患者的方法，包括向患者施用有效量的所定义的苯并噻二唑衍生物和有效量的 COX-2 抑制剂。
• COMBINATIONS OF BENZODITHIAZOLES AND COX-2 INHIBITORS FOR THE TREATMENT OF PAIN
  申请人：Novartis AG

  公开号：EP1556042A2

  公开（公告）日：2005-07-27
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSES ORGANIQUES
  申请人：NOVARTIS AG

  公开号：WO2004035030A2

  公开（公告）日：2004-04-29

  A pharmaceutical composition for treatment of pain, comprises in combination a benzothiadiazole derivative as defined and a COX-2 inhibitor for simultaneous, sequential or separate use. Also provided is a method of treating a patient suffering from pain, comprising administering to the patient an effective amount of a benzothiadiazole derivative as defined and an effective amount of a COX-2 inhibitor.