((4-chlorobutoxy)methanetriyl)tribenzene | 120586-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: ((4-chlorobutoxy)methanetriyl)tribenzene
• 英文别名: 1-Chlor-4-triphenylmethoxybutan；1-Chloro-4-triphenylmethoxybutane；[4-chlorobutoxy(diphenyl)methyl]benzene
• CAS: 120586-60-9
• 化学式: C₂₃H₂₃ClO
• 分子量: 350.888
• InChiKey: LEPBKNGJYHWWAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  ((4-chlorobutoxy)methanetriyl)tribenzene 、 酞酰亚胺-15N钾盐 以90%的产率得到
  参考文献：
  名称：

  BOIGEGRAIN, ROSE ANNE;FANELLI, ROBERTO;GARIBOLDI, PIERLUIGI;AIROLDI, LUIS+, J. LABELL. COMPOUNDS AND RADIOPHARM., 25,(1988) N 10, C. 1163-1172

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯丁醇 、 三苯基氯甲烷 在 2,6-二叔丁基吡啶 、 silver trifluoromethanesulfonate 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以63%的产率得到((4-chlorobutoxy)methanetriyl)tribenzene
  参考文献：
  名称：

  Mild and Adaptable Silver Triflate-Assisted Method for Trityl Protection of Alcohols in Solution with Solid-Phase Loading Applications

  摘要：

  Trityl ethers were prepared in solution in a matter of minutes by treating trityl chloride with silver triflate in the presence of alcohols. Yields were comparable or better than known literature methods. The method was compatible with the base-labile Fmoc protecting group of amino alcohols and adapted for trityl protection of halo-containing alcohols. These base- and nucleophile-sensitive intermediates were anchored on trityl resin and further functionalized, displaying the utility of this approach for future combinatorial applications.

  DOI：

  10.1021/ol0614018

文献信息

• Synthesis of phosphatidyldiols
  作者：Yul G. Molotkovskii、V. I. Kozhukhov、L. D. Bergel'son

  DOI：10.1007/bf00849353

  日期：1971.1
• BOIGEGRAIN, ROSE ANNE;FANELLI, ROBERTO;GARIBOLDI, PIERLUIGI;AIROLDI, LUIS+, J. LABELL. COMPOUNDS AND RADIOPHARM., 25,(1988) N 10, C. 1163-1172
  作者：BOIGEGRAIN, ROSE ANNE、FANELLI, ROBERTO、GARIBOLDI, PIERLUIGI、AIROLDI, LUIS+

  DOI：——

  日期：——
• Mild and Adaptable Silver Triflate-Assisted Method for Trityl Protection of Alcohols in Solution with Solid-Phase Loading Applications
  作者：Lundquist、Andrew D. Satterfield、Jeffrey C. Pelletier

  DOI：10.1021/ol0614018

  日期：2006.8.1

  Trityl ethers were prepared in solution in a matter of minutes by treating trityl chloride with silver triflate in the presence of alcohols. Yields were comparable or better than known literature methods. The method was compatible with the base-labile Fmoc protecting group of amino alcohols and adapted for trityl protection of halo-containing alcohols. These base- and nucleophile-sensitive intermediates were anchored on trityl resin and further functionalized, displaying the utility of this approach for future combinatorial applications.