tert-butyldiphenylsilyl ether | 100288-60-6

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tert-butyldiphenylsilyl ether
• 英文别名: diphenyl-tert-butylsilyl ether；t-butyldiphenylsilyl ether；tert-butyl-[tert-butyl(diphenyl)silyl]oxy-diphenylsilane
• CAS: 100288-60-6
• 化学式: C₃₂H₃₈OSi₂
• 分子量: 494.824
• InChiKey: KJTULOVPMGUBJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.12
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tert-butyldiphenylsilyl ether 在 吡啶 作用下， 生成 methyl 6-O-tert-butyldiphenylsilyl-2,3,4-tri-O-(4-methylbenzoyl)-1-thio-β-D-galactopyranoside
  参考文献：
  名称：

  Stereoselective syntheses of phosphorylated and sulfated glycosyl serines in glycosaminoglycan for biological probes

  摘要：

  Phosphorylated glycosyl serines of glycosaminoglycan with/without sulfate: beta-D-Xyl(2P)-Ser (1) and beta-D-Gal(+/-6S)-(1-->4)-beta-D-Xyl(2P)-Ser (2, 3) were suitably designed for biological probes. These oligosaccharides were synthesized in a stereocontrolled manner. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00300-5
• 作为产物：
  描述：

  咪唑 、 叔丁基二苯基氯硅烷 以 N,N-二甲基甲酰胺 为溶剂， 以83%的产率得到tert-butyldiphenylsilyl ether
  参考文献：
  名称：

  Palladium catalyzed alkylative cyclization useful in synthesis of

  摘要：

  提供了一种烷基化环加成方法，特别适用于合成许多具有不同侧链的维生素D类似物。因此，一种首选的合成是具有侧链R.sub.1的维生素D类似物，其中提供了具有结构##STR1##的基本上几何纯的第一前体和第二前体，第二前体是1,7-烯炔。在钯催化剂的存在下，这些前体反应形成具有结构##STR2##的化合物，其中R.sub.2是氢、羟基、较低的烷氧基、氟或保护基，而R.sub.3是氢、羟基、较低的烷氧基、氟或保护基。

  公开号：

  US05292977A1

文献信息

• Stereoselective total synthesis and stereochemistry confirmation of photo-mycolactones
  作者：Xiaoyong Li、Vaddela Sudheer Babu、Yoshito Kishi

  DOI：10.1016/j.tetlet.2014.12.024

  日期：2015.6

  With use of the LiTMP-induced Hodgson cyclopropanation of an epoxide-olefin to a bicyclo[3.1.0]hexanol as the key step, a stereoselective total synthesis of photo-mycolactones was achieved. Each of the four diastereomeric epoxide-olefins, selectively prepared from (R)- and (S)-glycidols, yielded the corresponding unique bicyclo[3.1.0]hexanol. Four bicyclo[3.1.0]hexanols 16, dia-16, 19, and dia-19 were

  使用LiTMP诱导的环氧烯烃至双环[3.1.0]己醇的霍奇森环丙烷化作为关键步骤，实现了光-甲基内酯的立体选择性全合成。由（R）-和（S）-糖醇选择性地制备的四种非对映体环氧烯烃中的每一种，产生相应的独特的双环[3.1.0]己醇。四双环[3.1.0]己醇16，直径- 16，19，和直径- 19转化成四伯醇17，直径- 17，20，和直径- 20，是以前关于光-内酯的研究中使用的中间体。该合成证实了先前提出的用于光-甲基内酯的立体化学。
• Preparation of cyclic peptide antifungal agents
  申请人：ELI LILLY AND COMPANY

  公开号：EP0906915A1

  公开（公告）日：1999-04-07

  The present invention provides phosphonylating agents and phosphonylation conditions that are compatible with the acid- and base-sensitive compounds and which promote a regioselective and reproducible conversion to a phosphonate compound. Also provided are intermediates that may be used to prepare phosphonate derivatives of cyclic peptides antifungal agent and a process for converting the phosphonates to the desired phosphonic acid prodrugs.

  本发明提供了与酸和碱敏感化合物相容的磷酸化试剂和磷酸化条件，并促进了对磷酸酯化合物的区域选择性和可重复转化。还提供了可用于制备环肽抗真菌剂的磷酸酯衍生物的中间体，以及将磷酸酯转化为所需的磷酸酯前药的过程。
• 화학적 합성에 의한 카나마이신 A로부터 카나마이신 X의 제조방법
  申请人：Ewha University - Industry Collaboration Foundation 이화여자대학교 산학협력단(220040083301) BRN ▼110-82-10456

  公开号：KR20210053796A

  公开（公告）日：2021-05-12

  본 발명은, 화학적 합성 방법을 이용하는, 카나마이신 A로부터, 1-N-(S-4-아미노-2-히드록시부티르산)-카나마이신 X(1-N-(S-4-amino-2-hydroxybutyric acid)-kanamycin X; 1-N-AHBA-kanamycin X) 합성을 위한 중간체인, 카나마이신 X의 제조방법에 관한 것이다.

  本发明涉及一种使用化学合成方法，从卡那霉素A中合成卡那霉素X（1-N-(S-4-氨基-2-羟基丁酸)-卡那霉素X；1-N-AHBA-卡那霉素X）的中间体的制备方法。
• Pentacyclic Alkaloid Compounds and Methods of Use Thereof
  申请人：Danishefsky Samuel J.

  公开号：US20090325971A1

  公开（公告）日：2009-12-31

  The present invention relates to Pentacyclic Alkaloid Compounds, compositions comprising an effective amount of a Pentacyclic Alkaloid Compound and methods for treating or preventing cancer, a bacterial infection, a fungal infection, or a yeast infection, comprising administering to a subject in need thereof an effective amount of a Pentacyclic Alkaloid Compound. The present invention also relates to compounds and methods that are useful for making Cribrostatin IV.

  本发明涉及五环生物碱化合物，包含有效量的五环生物碱化合物的组合物以及治疗或预防癌症、细菌感染、真菌感染或酵母菌感染的方法，包括向需要的受体中施用有效量的五环生物碱化合物。本发明还涉及有用于制备Cribrostatin IV的化合物和方法。
• Stereoselective syntheses of phosphorylated and sulfated glycosyl serines in glycosaminoglycan for biological probes
  作者：Jun-ichi Tamura、Junko Nishihara

  DOI：10.1016/s0960-894x(99)00300-5

  日期：1999.7

  Phosphorylated glycosyl serines of glycosaminoglycan with/without sulfate: beta-D-Xyl(2P)-Ser (1) and beta-D-Gal(+/-6S)-(1-->4)-beta-D-Xyl(2P)-Ser (2, 3) were suitably designed for biological probes. These oligosaccharides were synthesized in a stereocontrolled manner. (C) 1999 Elsevier Science Ltd. All rights reserved.