ethyl 2-amino-4-(3-chlorophenyl)-7-hydroxy-4H-chromene-3-carboxylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: ethyl 2-amino-4-(3-chlorophenyl)-7-hydroxy-4H-chromene-3-carboxylate
• 化学式: C₁₈H₁₆ClNO₄
• 分子量: 345.8
• InChiKey: XRNZGDAMENDBJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Enzyme Inhibitors and Uses Thereof
  申请人：Chai Siew Yeen

  公开号：US20080194636A1

  公开（公告）日：2008-08-14

  The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the inhibitors of the present invention may be useful in therapeutic applications including enhancing memory and learning functions, regulating cellular glucose uptake and homeostasis, inducing labour and lactation, and other disorders or conditions wherein excessive or undesirable IRAP activity is implicated.
• [EN] ENZYME INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS D'ENZYMES ET LEURS UTILISATIONS
  申请人：FLOREY HOWARD INST

  公开号：WO2006026832A1

  公开（公告）日：2006-03-16

  The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the inhibitors of the present invention may be useful in therapeutic applications including enhancing memory and learning functions, regulating cellular glucose uptake and homeostasis, inducing labour and lactation, and other disorders or conditions wherein excessive or undesirable IRAP activity is implicated.