pyridin-4-yl(thiophen-3-yl)methanone | 21314-82-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: pyridin-4-yl(thiophen-3-yl)methanone
• 英文别名: 3-Thienyl-4'-pyridyl ketone；pyridine-4-yl-thiophene-3-yl-methanone
• CAS: 21314-82-9
• 化学式: C₁₀H₇NOS
• 分子量: 189.238
• InChiKey: VBWNWEIBAXXUIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  pyridin-4-yl(thiophen-3-yl)methanone 生成 4-(2-(4,5-Dihydro-1H-imidazol-2-yl)-1-thiophene-3-ylethyl)pyridine
  参考文献：
  名称：

  Oral hypoglycaemic agents

  摘要：

  式(I)的化合物，它们是可选择取代的2-(&ohgr;，&ohgr;-二芳基烷基)-4,5-二氢-1H-咪唑和2-(&ohgr;，&ohgr;-二芳基烷基)-1,4,5,6-四氢嘧啶及其与无机和有机酸的盐具有有趣的药理特性。因此，这些化合物在治疗2型糖尿病方面是有用的。

  公开号：

  US20020132812A1
• 作为产物：
  描述：

  在 (5,10,15,20-tetrakis(p-methoxyphenyl)-21H,23H-porphyrinate)cobalt(II) 、 氧气 、 sodium hydroxide 作用下， 以 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 8.0h， 以72%的产率得到pyridin-4-yl(thiophen-3-yl)methanone
  参考文献：
  名称：

  光催化可控和可见光选择性氧化吡啶鎓盐

  摘要：

  这项研究提出了两种不同的方法，以空气为末端氧化剂，可光催化控制和可见光诱导的吡啶鎓的选择性氧化。这些转变的关键是选择合适的光源和光催化剂。吡啶鎓通过氧介导的环加成，质子偶联电子转移（PCET），吡啶开环和再循环成功地转化为吡咯。另一途径是吡啶鎓在钴（II）的催化下通过自由基重排/好氧氧化选择性地形成4-羰基吡啶。

  DOI：

  10.1007/s11426-020-9958-6

文献信息

• Oral hypoglycaemic agents
  申请人：——

  公开号：US20020132812A1

  公开（公告）日：2002-09-19

  Compounds of formula (I) which are optionally substituted 2-(&ohgr;,&ohgr;-diarylalkyl)-4,5-dihydro-1H-imidazoles and 2-(&ohgr;,&ohgr;-diarylalkyl)-1,4,5,6-tetrahydropyrimidines and salts thereof with inorganic and organic acids have interesting pharmacological properties. Thus, the compounds are useful in the treatment of type 2 diabetes.

  式(I)的化合物，它们是可选择取代的2-(&ohgr;，&ohgr;-二芳基烷基)-4,5-二氢-1H-咪唑和2-(&ohgr;，&ohgr;-二芳基烷基)-1,4,5,6-四氢嘧啶及其与无机和有机酸的盐具有有趣的药理特性。因此，这些化合物在治疗2型糖尿病方面是有用的。
• [EN] 1,3-DIAZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS ORAL HYPOGLYCAEMIC AGENTS<br/>[FR] COMPOSES 1,3 DIAZHETEROCYCLIQUES ET UTILISATION DE CES DERNIERS COMME AGENTS HYPOGLYCEMIANTS
  申请人：NOVO NORDISK AS

  公开号：WO2002038559A1

  公开（公告）日：2002-05-16

  A compound of formula (I) wherein Y is selected from the ring systems (a), (b); R?1 and R2¿ are independently phenyl, naphthyl, thienyl, thiazolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, quinolyl, 3-4-dihydroquinolyl, 5,6,7,8-tetrahydroquinolyl, isoquinolyl, 3,4-dihydroisoquinolyl, 5,6,7,8-tetrahydroisoquinolyl, indolyl, benzo[b]thienyl, benzimidazozyl, 5,6,7,8-tetrahydroimidazo[1,5-a]pyridyl or benzthiazolyl each of which is optionally substituted. R?3 and R5¿ are independently hydrogen, C¿1-6? alkyl or halogen or when taken together R?3 and R5¿ form an additional bond between the carbon atoms which they are attached; R¿4? is hydrogen, C1-6alkyl, arylC1-6alkyl, C1-6-C(O)- or arylC1-6alkyl-C(O)-, X is -CR?18R19¿- wherein R?18 and R19¿ are independently hydrogen or C¿1-6?alkyl; n is 0, 1 or 2. Thus, the compounds are useful in the treatment of type 2 diabetes.
• Imidazolines as efficacious glucose-dependent stimulators of insulin secretion
  作者：P Jakobsen

  DOI：10.1016/s0223-5234(03)00041-2

  日期：2003.4

  Synthesis of a series of imidazolines with glucose dependent effects on insulin exocytosis from pancreatic P-cells is reported. Regioisomers and enantionters were found to exhibit marked differences in exocytotic effects as well as different activities on the K-ATP-channel- the (R (+)) isomer of 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-thiophene-2-ylethyl]pyridine (4a) and the (+) isomer of 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-thiophene-3-yiethyl]pyridine (4d) were found to give a significant increase in insulin release in contrast to Findings for their enantiomers-without influence on the K-ATP-channel. The (+) isomer (4a) showed glucose dependent insulin release from P-cells at concentrations above 2.5 mM and a marked glucose lowering effect in ob/ob mice as well as in fed but not in fasted rats. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
• Photocatalyst-controlled and visible light-enabled selective oxidation of pyridinium salts
  作者：Xiang-Jun Peng、Hai-Ping He、Qian Liu、Kun She、Bao-Qi Zhang、Heng-Shan Wang、Hai-Tao Tang、Ying-Ming Pan

  DOI：10.1007/s11426-020-9958-6

  日期：2021.5

  methods of photocatalytic-controlled and visible light-induced selective oxidation of pyridiniums with air as the terminal oxidant. The key to these transformations is to choose the appropriate light source and photocatalyst. Pyridiniums are successfully converted into pyrroles through oxygen-mediated cycloaddition, proton-coupled electron transfer (PCET), pyridine ring opening, and recyclization. The

  这项研究提出了两种不同的方法，以空气为末端氧化剂，可光催化控制和可见光诱导的吡啶鎓的选择性氧化。这些转变的关键是选择合适的光源和光催化剂。吡啶鎓通过氧介导的环加成，质子偶联电子转移（PCET），吡啶开环和再循环成功地转化为吡咯。另一途径是吡啶鎓在钴（II）的催化下通过自由基重排/好氧氧化选择性地形成4-羰基吡啶。