N-[2-(4-methylpiperazin-1-yl)ethoxy]methanimine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-[2-(4-methylpiperazin-1-yl)ethoxy]methanimine
• 化学式: C₈H₁₇N₃O
• 分子量: 171.24
• InChiKey: WSDJUJAJMOWCJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  28.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Ascochlorin derivative and use thereof as AMPK activator
  申请人：Hoshino Tatsuo

  公开号：US10968186B2

  公开（公告）日：2021-04-06

  An object of the present invention is to provide a novel ascochlorin derivative which activates adenosine monophosphate-activated protein kinase (AMPK), and is useful in the treatment or prevention of diseases or conditions that involve AMPK dysregulation. The present invention provides a compound presented by formula I, a pharmaceutically acceptable salt or a solvate thereof.

  本发明的目的是提供一种新型ascochlorin衍生物，该衍生物可激活单磷酸腺苷激活蛋白激酶（AMPK），并可用于治疗或预防涉及AMPK失调的疾病或病症。本发明提供了一种由式I表示的化合物、其药学上可接受的盐或溶液。
• Combination therapy using ascochlorin derivative
  申请人：Hoshino Tatsuo

  公开号：US11298358B2

  公开（公告）日：2022-04-12

  An object of the present invention is to provide a measure for treating or preventing a disease or condition that involves AMPK dysregulation, particularly a cancer. The present invention provides a combination therapy using a compound presented by formula (I), a pharmaceutically acceptable salt or a solvate thereof with an immune checkpoint inhibitor.

  本发明的目的是提供一种用于治疗或预防涉及AMPK异常调节的疾病或状况的方法，特别是癌症。本发明提供了一种组合疗法，使用由式(I)表示的化合物、药学上可接受的盐或溶剂化物与免疫检查点抑制剂相结合。
• ASCOCHLORIN DERIVATIVE AND USE THEREOF AS AMPK ACTIVATOR
  申请人：HOSHINO, Tatsuo

  公开号：EP3400209B1

  公开（公告）日：2021-09-22
• COMBINATION THERAPY USING ASCOCHLORIN DERIVATIVE
  申请人：HOSHINO Tatsuo

  公开号：US20210346390A1

  公开（公告）日：2021-11-11

  An object of the present invention is to provide a measure for treating or preventing a disease or condition that involves AMPK dysregulation, particularly a cancer. The present invention provides a combination therapy using a compound presented by formula (I), a pharmaceutically acceptable salt or a solvate thereof with an immune checkpoint inhibitor.