N-[(2S,3R)-1,3-dihydroxyhexadecan-2-yl]octadec-9-enamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: N-[(2S,3R)-1,3-dihydroxyhexadecan-2-yl]octadec-9-enamide
• 化学式: C₃₄H₆₇NO₃
• 分子量: 537.9
• InChiKey: QVISLCKXNWPVSI-JHOUSYSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.4
• 重原子数：
  38
• 可旋转键数：
  30
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Clear aqueous ceramide composition
  申请人：Takasago International Corporation

  公开号：EP1153595A2

  公开（公告）日：2001-11-14

  Provided is a clear aqueous ceramide composition comprising 1.0 to 5.0% by weight, based on the total composition, of a ceramide represented by formula (I): wherein R1 represents a hydrocarbon group having 9 to 17 carbon atoms; and R2 represents an acyl group having 2 to 30 carbon atoms which can contain a hydroxyl group, a long-chain fatty acid having 12 to 24 carbon atoms, a nonionic surface active agent, and water. The clear aqueous composition is useful as cosmetics, bath agents, hair-careproducts, external preparations for the skin, skin protective preparations, particularly medical external preparations for the treatment or protection of the skin, or a component making up these preparations.

  本发明提供了一种透明的含水神经酰胺组合物，该组合物含有按重量计为 1.0 至 5.0%的由式(I)代表的神经酰胺： 其中 R1 代表具有 9 至 17 个碳原子的烃基；R2 代表具有 2 至 30 个碳原子的酰基，该酰基可含有羟基、 具有 12 至 24 个碳原子的长链脂肪酸、非离子表面活性剂和水。这种透明的水性组合物可用作化妆品、沐浴剂、护发产品、皮肤外用制剂、皮肤保护制剂，特别是用于治疗或保护皮肤的医用外用制剂，或这些制剂的组成部分。
• Humectant Composition
  申请人：Takasago International Corporation

  公开号：EP1946743A2

  公开（公告）日：2008-07-23

  The present invention relates to a humectant composition containing, as component (A), at least one member selected from a menthol derivative represented by the following formula (1) and p-menthane-3,8-diol: in which R is an alkylene group having 2 to 5 carbon atoms which may be substituted with at least one member selected from the group consisting of a methyl group and a hydroxyl group, and n is an integer of 1 to 3. The humectant composition of the present invention provides an excellent moisture-retention effect.

  本发明涉及一种保湿剂组合物，其中含有至少一种选自下式（1）所代表的薄荷醇衍生物和对薄荷-3,8-二醇的成分（A）： 本发明的保湿剂组合物具有优异的保湿效果。
• Lipid composition and skin care formulation containing the same
  申请人：Ishida Kenya

  公开号：US20060210522A1

  公开（公告）日：2006-09-21

  Bioavailability of a ceramide, which is a minimally soluble material of a skin care composition exhibiting an excellent effect is enhanced by combining at least one component selected from ceramides represented by Formula (1): and at least one component selected from aliphatic alcohol having 12 to 30 carbon atoms.

  将至少一种选自由式（1）表示的神经酰胺的成分与至少一种选自具有 12 至 30 个碳原子的脂肪醇的成分结合，可提高神经酰胺的生物利用率，神经酰胺是护肤组合物中具有优异功效的微溶性材料： 和至少一种选自具有 12 至 30 个碳原子的脂肪醇的成分。
• LIPID COMPOSITION AND SKIN CARE FORMULATION CONTAINING THE SAME
  申请人：Takasago International Corporation

  公开号：EP1633313B1

  公开（公告）日：2016-12-07
• HUMECTANT COMPOSITION
  申请人：Yamamoto Tetsuya

  公开号：US20080171794A1

  公开（公告）日：2008-07-17

  The present invention relates to a humectant composition containing, as component (A), at least one member selected from a menthol derivative represented by the following formula (1) and p-menthane-3,8-diol: in which R is an alkylene group having 2 to 5 carbon atoms which may be substituted with at least one member selected from the group consisting of a methyl group and a hydroxyl group, and n is an integer of 1 to 3. The humectant composition of the present invention provides an excellent moisture-retention effect.