4-Cyclopentyl-3-(4-methoxyphenyl)-1-(2-phenylethyl)piperazine-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-Cyclopentyl-3-(4-methoxyphenyl)-1-(2-phenylethyl)piperazine-2,5-dione
• 化学式: C₂₄H₂₈N₂O₃
• 分子量: 392.5
• InChiKey: YGLQFADYNCLGSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR TREATING, PREVENTING AND DIAGNOSING CANCER AND OTHER PROLIFERATIVE DISORDERS
  申请人：Angiogenex, Inc.

  公开号：EP3079680A2

  公开（公告）日：2016-10-19
• [EN] COMPOSITIONS AND METHODS FOR TREATING, PREVENTING AND DIAGNOSING CANCER AND OTHER PROLIFERATIVE DISORDERS<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT, DE PRÉVENTION ET DE DIAGNOSTIC DU CANCER ET D'AUTRES MALADIES PROLIFÉRATIVES
  申请人：ANGIOGENEX INC

  公开号：WO2015089495A2

  公开（公告）日：2015-06-18

  The present invention provides methods for impairing function or reducing or ablating levels of Id (inhibitors of differentiation) proteins to suppress metastasis of cancer cells in mammalian subjects presenting with cancer or elevated risk of metastatic disease. Exemplary anti-Id compounds include N-(3-(benzo[d] [1,3]dioxol-5-yl)-3-(2-methoxyphenyl)propyl)-N- benzylpropionamide and isolated enantiomers of N-(3-(benzo[d] [ 1,3]dioxol-5-yl)-3-(2- methoxyphenyl)propyl)-N-benzylpropionamide. Anti-Id compositions and methods of the invention can be combined with standard anticancer treatment modalities, such as surgery, radiation and chemotherapy. Also provided are compositions and methods to treat other hyperproliferative disorders, including pathogenic angiogenic conditions, including tumor-associated neoangiogenesis and ocular vascular pathologies including age-related macular degeneration.