ethyl 3-methylamino-2-methyl-2-butenoate | 88785-67-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯基酰胺
• 英文名称: ethyl 3-methylamino-2-methyl-2-butenoate
• 英文别名: ethyl (E)-2-methyl-3-(methylamino)prop-2-enoate
• CAS: 88785-67-5
• 化学式: C₇H₁₃NO₂
• 分子量: 143.186
• InChiKey: ZVENIQHUUNMZNA-AATRIKPKSA-N

物化性质

• 沸点：
  207.9±23.0 °C(Predicted)
• 密度：
  0.955±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl (Z)-3-(methylamino)-2-butenoate 、 碘甲烷 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 ethyl 3-methylamino-2-methyl-2-butenoate
  参考文献：
  名称：

  Shabana, R.; Rasmussen, J. B.; Lawesson, S.-O., Bulletin des Societes Chimiques Belges, 1981, vol. 90, # 1, p. 75 - 82

  摘要：

  DOI：

文献信息

• [EN] CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF<br/>[FR] MODULATEURS DE CALPAÏNE ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：BLADE THERAPEUTICS INC

  公开号：WO2019190885A1

  公开（公告）日：2019-10-03

  Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by contacting them with CAPN1, CAPN2, and/or CAPN9 enzymes residing inside a subject. The compounds and composition can also be administered to a subject in order to treat a fibrotic disease or a secondary disease state or condition of a fibrotic disease.

  小分子钙蛋白酶调节剂化合物，包括其药用可接受的盐，可以包含在药物组合物中。这些化合物可以通过与主体内的CAPN1、CAPN2和/或CAPN9酶接触来抑制钙蛋白酶，或与钙蛋白酶抑制剂竞争性结合。这些化合物和组合物也可以被用于治疗纤维化疾病或纤维化疾病的继发疾病状态或病情。
• Carrier Resins with Improved Relative Humidity Sensitivity
  申请人：Xerox Corporation

  公开号：US20150183899A1

  公开（公告）日：2015-07-02

  The disclosure describes dry acrylate resin particles, optionally, with a C/O of at least about 4, comprising a heterocycle comprising sulfur, exhibiting high charge and improved RH sensitivity.

  该披露描述了干燥的丙烯酸酯树脂颗粒，可选地，其碳/氧比至少约为4，包括含硫的杂环，表现出高电荷和改善的相对湿度敏感性。
• Polymer compositions and their production
  申请人：SCM CORPORATION

  公开号：EP0017911A1

  公开（公告）日：1980-10-29

  Increasing the solids content of an aqueous dispersoid of: (a) a resin having aliphatic backbone carbons; (b) addition polymer, and (c) graft polymer consisting of addition polymer grafted to the aliphatic carbon atoms of said resin; which comprises bringing together ethylenically unsaturated monomer, initiator, and such dispersoid, and polymerizing the such monomer in situ. Preferred products produced are water-reducible epoxy resin-based. These are produced by a process which comprises initiating addition polymerization of ethylenically unsaturated monomer in the presence of such dispersoid.

  增加水性分散体的固体含量： (a) 具有脂肪族骨架碳的树脂； (b) 加成聚合物，以及 (c) 接枝聚合物，包括接枝到所述树脂脂肪族碳原子上的接枝聚合物； 其中包括将乙烯不饱和单体、引发剂和此类分散体混合在一起，并在原位聚合此类单体。 生产的首选产品是以水减性环氧树脂为基础的产品。这些产品的生产工艺包括在这种分散体存在的情况下引发乙烯基不饱和单体的加成聚合。
• Primer composition
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0842991A1

  公开（公告）日：1998-05-20

  In order to provide a general-purpose aqueous primer composition requiring no organic solvent and capable of improving adhesive strength and durability while ensuring an adequate application life required for the work of primer coating process, a primer composition according to the present invention contains (a) a modified polyisocyanate obtained by reaction of polyisocyanate; an emulsifying agent having an active hydrogen group reactable to an isocyanate group; and a silane coupling agent having an active hydrogen group reactable to an isocyanate group and (b) a core shell emulsion having a core layer of a rubbery polymer and a shell layer of a glassy polymer and having an active hydrogen group reactable to an isocyanate group in the core layer and/or the shell layer.

  为了提供一种不需要有机溶剂的通用水性底漆组合物，该组合物能够提高粘合强度和耐久性，同时确保底漆涂装工艺工作所需的足够的涂装寿命，根据本发明的底漆组合物包含(a)由多异氰酸酯反应得到的改性多异氰酸酯；具有可与异氰酸酯基反应的活性氢基的乳化剂；和具有可与异氰酸酯基反应的活性氢基的硅烷偶联剂；以及 (b) 具有橡胶聚合物芯层和玻璃聚合物外壳层的芯壳乳液，芯层和/或外壳层中具有可与异氰酸酯基反应的活性氢基。
• Smart polymer materials with excess reactive molecules
  申请人：MEDIPACS, INC

  公开号：US10000605B2

  公开（公告）日：2018-06-19

  A three-dimensional smart polymer matrix is formed by a first epoxy chemical reaction linking a linear polymer chain and a branched polymer chain, wherein the polymer chains are flexible and one or more reactive molecule species remain unreacted, at a predetermined mathematical ratio of reacted to un-reacted molecules and molecule species, and the un-reacted molecular species are available for further chemical reaction, protonation or deprotonation after the first chemical reaction. The resulting smart polymer matrix is hydrophilic and non-soluble to a solvent or electrolyte.

  一种三维智能聚合物基体是通过连接线性聚合物链和支链聚合物链的第一环氧化学反应形成的，其中聚合物链是柔性的，一个或多个反应分子种类保持未反应状态，已反应与未反应分子和分子种类的数学比率是预定的，未反应分子种类在第一化学反应后可用于进一步的化学反应、质子化或去质子化。由此产生的智能聚合物基质具有亲水性，不溶于溶剂或电解质。