1-Cyclopropyl-4-propylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-Cyclopropyl-4-propylpiperazine
• 英文别名: 1-cyclopropyl-4-propylpiperazine
• 化学式: C₁₀H₂₀N₂
• 分子量: 168.28
• InChiKey: QEXVOPWEOQCKMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] NOVEL BENZIMIDAZOLE COMPOUND<br/>[FR] NOUVEAU COMPOSÉ DE BENZIMIDAZOLE<br/>[ZH] 新型苯并咪唑化合物
  申请人：WIGEN BIOMEDICINE TECH SHANGHAI CO LTD

  公开号：WO2022002100A1

  公开（公告）日：2022-01-06

  本发明涉及一种通式(1)所示的化合物及其制备方法，及通式(1)化合物及其各异构体、各晶型、药学上可接受的盐、水合物或溶剂合物作为EGFR抑制剂在抗肿瘤等EGFR相关疾病的药物制备中的用途。
• DIANILINOPYRIMIDINE COMPOUND FOR INHIBITING KINASE ACTIVITY
  申请人：Shenzhen TargetRx, Inc.

  公开号：US20210087213A1

  公开（公告）日：2021-03-25

  Disclosed are a dianilinopyrimidine compound having an inhibitory effect on protein tyrosine kinase, pharmaceutically acceptable salts, crystal forms, prodrugs, metabolites, hydrates, solvates, stereoisomers or isotopic derivatives thereof, a pharmaceutical composition containing these compounds, as well as preparation and use of these compounds. The compound has a structure as represented by formula (I), and may be used for treating ALK-mediated cancer-related symptoms, such as non-small cell lung cancer, breast cancer, nerve tumors, esophagus cancer, soft tissue cancer, lymphoma, or leukemia.