2-(4-(2,5-Dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-(2,5-Dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)ethanol
• 英文别名: 2-[4-(2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol
• 化学式: C₂₀H₂₅N₅O
• 分子量: 351.4
• InChiKey: AMGSSOTZVXYAGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  56.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Methods and compositions for KRAS inhibitors
  申请人：The Board of Regents, The University of Texas System

  公开号：US11141418B1

  公开（公告）日：2021-10-12

  In one aspect, the disclosure relates to compounds that are inhibitors of KRAS, and the disclosed compounds are allosteric inhibitors of KRAS which render them extremely useful for therapeutic intervention in a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, e.g., cancer. In various aspects, the disclosed compounds are substituted 7-(piperazin-1-yl)pyrazolo[1,5-a]pyrimidine analogs. In further aspects, the disclosed compounds can be used in methods of treating a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

  在一个方面，本公开涉及的化合物是KRAS的抑制剂，所公开的化合物是KRAS的异构抑制剂，这使得它们在各种疾病的治疗干预中极为有用，在这些疾病中，抑制DHODH在临床上是有用的，例如癌症。在各个方面，所公开的化合物是取代的 7-(哌嗪-1-基)吡唑并[1,5-a]嘧啶类似物。在进一步的方面，所公开的化合物可用于治疗癌症的方法中。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本公开内容的限制。
• METHODS AND COMPOSITIONS FOR KRAS INHIBITORS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20210401845A1

  公开（公告）日：2021-12-30

  In one aspect, the disclosure relates to compounds that are inhibitors of KRAS, and the disclosed compounds are allosteric inhibitors of KRAS which render them extremely useful for therapeutic intervention in a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, e.g., cancer. In various aspects, the disclosed compounds are substituted 7-(piperazin-1-yl)pyrazolo[1,5-a]pyrimidine analogs. In further aspects, the disclosed compounds can be used in methods of treating a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.