[(5S)-3-[3-fluoro-4-[4-(3-thiophen-2-ylprop-2-enoyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methylthiourea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [(5S)-3-[3-fluoro-4-[4-(3-thiophen-2-ylprop-2-enoyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methylthiourea
• 化学式: C₂₂H₂₄FN₅O₃S₂
• 分子量: 489.6
• InChiKey: PAADKMGOWLKFFQ-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  152
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Novel antiinfective compounds, process for their preparation and pharmaceutical compositions containing them
  申请人：Lohray B. Braj

  公开号：US20060229316A1

  公开（公告）日：2006-10-12

  The present invention describes novel antiinfective compounds, process for their preparation and pharmaceutical compositions containing them.

  本发明描述了新型抗感染化合物，其制备过程以及含有它们的药物组成物。
• ANTIINFECTVE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：CADILA HEALTHCARE LTD.

  公开号：EP1495021A2

  公开（公告）日：2005-01-12
• [EN] ANTIINFECTVE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES ANTI-INFECTIEUX, PROCESSUS DE PREPARATION DE CES COMPOSES ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2003082864A2

  公开（公告）日：2003-10-09

  The present invention relates to novel compounds of general formula (I), their analogs, their derivatives, their stereoisomers, tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (I), their analogs, their derivatives, their stereoisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutical compositions containing them, and novel intermediates (I) involved in their synthesis. The compound of the present invention is useful in the treatment of a number of human and veterinary pathogens, including aerobic as well as anaerobic Gram-positive and Gram-negative organisms.