4-(3-Nitro-4-piperidin-1-ylphenyl)phthalazin-1(2H)-one | 218144-45-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(3-Nitro-4-piperidin-1-ylphenyl)phthalazin-1(2H)-one
• 英文别名: 4-(3-nitro-4-piperidin-1-ylphenyl)-2H-phthalazin-1-one
• CAS: 218144-45-7
• 化学式: C19H18N4O3
• mdl: MFCD00116203
• 分子量: 350.4
• InChiKey: ZZVUHPJVOJWXPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  90.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SMALL MOLECULE MODULATORS OF CYTOKINE ACTIVITY
  申请人：Zembower David E.

  公开号：US20100137285A1

  公开（公告）日：2010-06-03

  The present invention provides compounds having formula (I) or (II): and pharmaceutically acceptable derivatives thereof, wherein m, p, R 1 , R 2 , R 3 and R 4 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of diseases, disorders or conditions associated with HGF/SF or other cytokine activity.
• HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES
  申请人：Paka Latha

  公开号：US20100256117A1

  公开（公告）日：2010-10-07

  Methods are provided for treating fibrotic connective tissue diseases such as scleroderma and conditions such as surgically-induced adhesions using compounds that activate the signaling pathways of hepatocyte growth factor.
• ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  申请人：Oehlen Lambertus J.W.M.

  公开号：US20120190668A1

  公开（公告）日：2012-07-26

  The present invention provides methods for enhancing cellular transplantation by exposing cells in vitro or ex vivo, or a recipient of cells, to a small molecule hepatocyte growth factor/scatter factor mimetic. Exemplary compounds are described.
• ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  申请人：ANGION BIOMEDICA CORP

  公开号：US20140171419A1

  公开（公告）日：2014-06-19

  The present invention provides methods for enhancing cellular transplantation by exposing cells in vitro or ex vivo, or a recipient of cells, to a small molecule hepatocyte growth factor/scatter factor mimetic. Exemplary compounds are described.
• US7648978B2
  申请人：——

  公开号：US7648978B2

  公开（公告）日：2010-01-19