4-(4-Chloro-benzyl)-1-cyclohexyl-3-(4-methoxy-phenyl)-piperazine-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-Chloro-benzyl)-1-cyclohexyl-3-(4-methoxy-phenyl)-piperazine-2,5-dione
• 英文别名: 4-[(4-Chlorophenyl)methyl]-1-cyclohexyl-3-(4-methoxyphenyl)piperazine-2,5-dione
• 化学式: C₂₄H₂₇ClN₂O₃
• 分子量: 426.943
• InChiKey: LEXCUWMUXIWOKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-[(2-Chloro-acetyl)-(4-chloro-benzyl)-amino]-N-cyclohexyl-2-(4-methoxy-phenyl)-acetamide 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以72%的产率得到4-(4-Chloro-benzyl)-1-cyclohexyl-3-(4-methoxy-phenyl)-piperazine-2,5-dione
  参考文献：
  名称：

  A facile synthesis of 2,5-diketopiperazines based on isocyanide chemistry

  摘要：

  The Ugi four-component condensation (4-CC) between amines 4, aromatic aldehydes 5, chloroacetic acid 6 and isocyanides 7 afforded the expected 4-CC adducts 8 which were cyclised to the title compounds 9 upon treatment with ethanolic KOH under ultrasonication. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00232-5

文献信息

• A facile synthesis of 2,5-diketopiperazines based on isocyanide chemistry
  作者：Stefano Marcaccini、Roberto Pepino、Ma̱ Cruz Pozo

  DOI：10.1016/s0040-4039(01)00232-5

  日期：2001.4

  The Ugi four-component condensation (4-CC) between amines 4, aromatic aldehydes 5, chloroacetic acid 6 and isocyanides 7 afforded the expected 4-CC adducts 8 which were cyclised to the title compounds 9 upon treatment with ethanolic KOH under ultrasonication. (C) 2001 Elsevier Science Ltd. All rights reserved.