1-(6-trifluoromethylpyridin-3-yl)piperazin-1-ium trifluoroacetate | 1258838-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(6-trifluoromethylpyridin-3-yl)piperazin-1-ium trifluoroacetate
• 英文别名: 1-(6-Trifluoromethyl-pyridin-3-yl)-piperazin-1-ium trifluoroacetate；2,2,2-trifluoroacetate;1-[6-(trifluoromethyl)pyridin-3-yl]piperazin-1-ium
• CAS: 1258838-48-0
• 化学式: C₂HF₃O₂*C₁₀H₁₂F₃N₃
• 分子量: 345.245
• InChiKey: OXROMEAOHBFMDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.48
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  69.5
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  tert-butyl 4-[6-(trifluoromethyl)pyridin-3-yl]piperazine-1-carboxylate 、 三氟乙酸 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 1-(6-trifluoromethylpyridin-3-yl)piperazin-1-ium trifluoroacetate
  参考文献：
  名称：

  [EN] ANTHELMINTIC AGENTS AND THEIR USE
  [FR] AGENTS ANTHELMINTHIQUES ET LEUR UTILISATION

  摘要：

  这项发明涉及通式（I）的化合物及其盐，通常可用作驱虫剂或作为制备驱虫剂的中间体。这项发明还涉及制备这些化合物的方法，包括这些化合物的药物组合物和试剂盒，利用这些化合物制备药物的用途，以及将这些化合物用于给予需要治疗的动物的治疗。

  公开号：

  WO2010146083A1

文献信息

• ANTHELMINTIC AGENTS AND THEIR USE
  申请人：Chassaing Christophe Pierre Alain

  公开号：US20120094981A1

  公开（公告）日：2012-04-19

  This invention is directed to compounds of the formula (I) and salts therefore that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds of this invention, pharmaceutical compositions and kits comprising the compounds of this invention, uses of the compounds of this invention to make medicaments, and treatments comprising the administration of the compounds of this invention to animals in need of the treatments.

  本发明涉及公式（I）的化合物及其盐，通常用作驱虫剂或作为制备驱虫剂的中间体。本发明还涉及制备本发明化合物的方法，包括本发明化合物的制药组合物和试剂盒，使用本发明化合物制备药物的用途，以及将本发明化合物用于需要治疗的动物的治疗。
• Anthelmintic agents and their use
  申请人：Chassaing Christophe Pierre Alain

  公开号：US08507474B2

  公开（公告）日：2013-08-13

  This invention is directed to compounds of the formula (I) and salts therefore that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds of this invention, pharmaceutical compositions and kits comprising the compounds of this invention, uses of the compounds of this invention to make medicaments, and treatments comprising the administration of the compounds of this invention to animals in need of the treatments.

  本发明涉及公式（I）的化合物及其盐，通常作为驱虫剂或作为制备驱虫剂的中间体有用。本发明还涉及制备本发明化合物的方法，包含本发明化合物的制药组合物和工具箱，使用本发明化合物制备药物的用途，以及将本发明化合物用于治疗需要治疗的动物的治疗方法。
• US8507474B2
  申请人：——

  公开号：US8507474B2

  公开（公告）日：2013-08-13
• [EN] ANTHELMINTIC AGENTS AND THEIR USE<br/>[FR] AGENTS ANTHELMINTHIQUES ET LEUR UTILISATION
  申请人：INTERVET INT BV

  公开号：WO2010146083A1

  公开（公告）日：2010-12-23

  This invention is directed to compounds of the formula (I) and salts therefore that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds of this invention, pharmaceutical compositions and kits comprising the compounds of this invention, uses of the compounds of this invention to make medicaments, and treatments comprising the administration of the compounds of this invention to animals in need of the treatments.

  这项发明涉及通式（I）的化合物及其盐，通常可用作驱虫剂或作为制备驱虫剂的中间体。这项发明还涉及制备这些化合物的方法，包括这些化合物的药物组合物和试剂盒，利用这些化合物制备药物的用途，以及将这些化合物用于给予需要治疗的动物的治疗。