Carbonic acid, 2-ethylhexyl propyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: Carbonic acid, 2-ethylhexyl propyl ester
• 英文别名: 2-ethylhexyl propyl carbonate
• 化学式: C₁₂H₂₄O₃
• 分子量: 216.32
• InChiKey: DYLAGBPDKPQGPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Prodrugs of NH-acidic compounds
  申请人：Alkermes Pharma Ireland Limited

  公开号：US10040787B2

  公开（公告）日：2018-08-07

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  本发明提供了一种持续给药含有内酰胺、酰亚胺、酰胺、磺酰胺、氨基甲酸酯或脲的母体药物的方法，其方法是向患者给药有效量的本发明原药化合物，给药后，母体药物从原药中持续释放。适用于本发明方法的原药化合物是通过羰基连接的原药分子进行衍生的母药的易变共轭物。本发明的原药化合物可用于治疗任何含有内酰胺、亚胺、酰胺、磺酰胺、氨基甲酸酯或脲的母药可用于治疗的病症。
• Process for synthesizing oxidized lactam compounds
  申请人：Alkermes Pharma Ireland Limited

  公开号：US10011569B2

  公开（公告）日：2018-07-03

  The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I:

  本发明提供了一种合成式 I 的脱氢内酰胺药物的方法：
• Heterocyclic compounds for the treatment of neurological and psychological disorders
  申请人：Alkermes Pharma Ireland Limited

  公开号：US11518745B2

  公开（公告）日：2022-12-06

  Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.

  公开了式 I 的内酰胺化合物及其在治疗神经和精神疾病（包括精神分裂症、躁郁症、焦虑症和失眠症）方面的用途。
• Prodrugs of NH-Acidic Compounds
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20170015659A1

  公开（公告）日：2017-01-19

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
• Process for Synthesizing Oxidized Lactam Compounds
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20170267639A1

  公开（公告）日：2017-09-21

  The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I: