9-Chloro-6-(3-methylpiperazin-1-yl)indeno[1,2-c]quinolin-11-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 9-Chloro-6-(3-methylpiperazin-1-yl)indeno[1,2-c]quinolin-11-one
• 英文别名: 9-chloro-6-(3-methylpiperazin-1-yl)indeno[1,2-c]quinolin-11-one
• 化学式: C₂₁H₁₈ClN₃O
• 分子量: 363.8
• InChiKey: CMCVGIROUQJQKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL INDENO[1,2-c]QUINOLIN-11-ONE DERIVATIVES, PREPARATION METHOD AND APPLICATION THEREOF
  申请人：National Defense Medical Center

  公开号：US20150197492A1

  公开（公告）日：2015-07-16

  The present invention provides a novel series of indeno[1,2-c]quinolin-11-one derivatives and further provides their preparation methods as well as applications. Said applications includes utilizing such derivatives as pharmaceutical compositions for treating cancers; moreover, said applications includes the capability possessed by such derivatives to effectively inhibit cancer cell growth as well as the activity of Type I topoisomerases and can be further applied for cancer treatment.

  本发明提供了一系列新颖的indeno[1,2-c]quinolin-11-one衍生物，并进一步提供其制备方法以及应用。所述应用包括将这些衍生物用作治疗癌症的药物组合物；此外，所述应用包括这些衍生物具有有效抑制癌细胞生长以及抑制Ⅰ型拓扑异构酶活性的能力，并可进一步应用于癌症治疗。