2-[4-[4-(2-Hydroxyphenyl)piperazin-1-yl]-4-oxobutyl]benzo[de]isoquinoline-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-[4-(2-Hydroxyphenyl)piperazin-1-yl]-4-oxobutyl]benzo[de]isoquinoline-1,3-dione
• 化学式: C₂₆H₂₅N₃O₄
• 分子量: 443.5
• InChiKey: PZLNJDMRGZJIDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  81.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ENHANCED ANTIBIOTIC COMPOSITION
  申请人：Universitat Autònoma de Barcelona

  公开号：EP3294317B1

  公开（公告）日：2020-12-09
• [EN] ENHANCED ANTIBIOTIC COMPOSITION<br/>[FR] COMPOSITION ANTIBIOTIQUE AMÉLIORÉE
  申请人：UNIV BARCELONA AUTONOMA

  公开号：WO2016180919A1

  公开（公告）日：2016-11-17

  The present invention relates to an enhanced antibiotic composition, which shows enhanced antimicrobial activity of antibiotics, in particular polymyxins, in front of multidrug resistant bacteria by combining them with specific potentiator compounds. It relates also to such composition foruse as a medicament, and such specific potentiator compounds for use as enhancers of the antibacterial activity of antibiotics.