2-imidazo[4,5-b]pyridin-3-yl-1-{(R)-2-methyl-4-[2-(2-propyl-pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinolin-8-yl]-piperazin-1-yl}-ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-imidazo[4,5-b]pyridin-3-yl-1-{(R)-2-methyl-4-[2-(2-propyl-pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinolin-8-yl]-piperazin-1-yl}-ethanone
• 英文别名: 2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-2-methyl-4-[2-(2-propyl-pyrimidin-5-yl)-1,2,3,4-tetrahydro-isoquinolin-8-yl]-piperazin-1-yl}-ethanone；2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-2-methyl-4-[2-(2-propylpyrimidin-5-yl)-3,4-dihydro-1H-isoquinolin-8-yl]piperazin-1-yl]ethanone
• 化学式: C₂₉H₃₄N₈O
• 分子量: 510.642
• InChiKey: LAVOROOPDUNDNN-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  83.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] 8-(PIPERAZIN-1-YL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE DERIVATIVES<br/>[FR] DÉRIVÉS 8- (PIPÉRAZIN -1-YL) -1,2,3,4-TÉTRAHYDRO-ISOQUINOLINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2015145322A1

  公开（公告）日：2015-10-01

  The invention relates to compounds of Formula (I) wherein R1, R2, R3, R4 and R5 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

  该发明涉及式（I）化合物，其中R1、R2、R3、R4和R5如描述中所述；其药用盐；以及将此类化合物用作药物，特别是作为CXCR3受体的调节剂。
• 8-(PIPERAZIN-1-YL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE DERIVATIVES
  申请人：Idorsia Pharmaceuticals Ltd

  公开号：EP3122741B1

  公开（公告）日：2018-06-06
• US9951063B2
  申请人：——

  公开号：US9951063B2

  公开（公告）日：2018-04-24