3-(2-Chloropropanoyl)-1-methylurea

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 3-(2-Chloropropanoyl)-1-methylurea
• 英文别名: 2-chloro-N-(methylcarbamoyl)propanamide
• 化学式: C₅H₉ClN₂O₂
• mdl: MFCD03982155
• 分子量: 164.59
• InChiKey: NIZMPYRTHWZLNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• COMPOUNDS SUITABLE FOR THE TREATMENT AND PROPHYLAXIS OF MUSCLE WASTING AND OTHER CONDITIONS
  申请人：Adams, Volker

  公开号：EP4013497A1

  公开（公告）日：2022-06-22
• [EN] COMPOUNDS SUITABLE FOR THE TREATMENT AND PROPHYLAXIS OF MUSCLE WASTING AND OTHER CONDITIONS<br/>[FR] COMPOSÉS ADAPTÉS AU TRAITEMENT ET À LA PROPHYLAXIE DE L'ATROPHIE MUSCULAIRE ET D'AUTRES AFFECTIONS
  申请人：ADAMS VOLKER

  公开号：WO2021032643A1

  公开（公告）日：2021-02-25

  The present invention relates to a compound of the general formula I and the pharmaceutically acceptable salts thereof; where the variables are as defined in the claims and the description. The invention also relates to the compounds of formula I for use in the treatment or prophylaxis of muscle wasting conditions, of skeletal or cardial muscle atrophy, of conditions, in particular of myopathies, which are associated with an increased Muscle RING Finger 1 (MuRF1) expression and of other conditions; to the compounds of formula I for use as a medicament; to a pharmaceutical composition comprising at least one compound of formula I and to a method for treating said conditions.