6-Brom-1,2,4-benzothiadiazin-1,1-dioxid | 37162-37-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 6-Brom-1,2,4-benzothiadiazin-1,1-dioxid
• 英文别名: 6-bromo-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide；6-bromo-4H-1lambda6,2,4-benzothiadiazine 1,1-dioxide；6-bromo-4H-1λ6,2,4-benzothiadiazine 1,1-dioxide
• CAS: 37162-37-1
• 化学式: C₇H₅BrN₂O₂S
• 分子量: 261.099
• InChiKey: MYMKIRPJJNWMMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-Brom-1,2,4-benzothiadiazin-1,1-dioxid 生成 6-bromo-7-iodo-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
  参考文献：
  名称：

  Di Bella; Monzani; Rinaldi, Farmaco, Edizione Scientifica, 1975, vol. 30, # 1, p. 47 - 57

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-4-溴-苯磺酰胺 在 原甲酸三乙酯 作用下， 以84.2 %的产率得到6-Brom-1,2,4-benzothiadiazin-1,1-dioxid
  参考文献：
  名称：

  ANILINO-PYRAZOLE DERIVATIVES, COMPOSITIONS AND METHODS THEREOF

  摘要：

  The invention provides novel anilino-pyrazole derivatives as a cyclin-dependent kinase 2 (CDK2) inhibitors. The invention also provides pharmaceutical compositions comprising the compounds and methods thereof for treating various conditions, diseases and disorders associated with or related to CDK2 activities, or associated with abnormal cell growth, such as tumor growth and cancer.

  公开号：

  WO2023244710A1

文献信息

• [EN] HETERO-BICYCLIC DERIVATIVES AS HCV INHIBITORS<br/>[FR] DÉRIVÉS HÉTÉRO-BICYCLIQUES EN TANT QU'INHIBITEURS DU VHC
  申请人：TIBOTEC PHARM LTD

  公开号：WO2012013643A1

  公开（公告）日：2012-02-02

  Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R and R' have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors,in HCV therapy.

  HCV复制抑制剂的化学式(I)包括立体化学异构形式，以及其盐、水合物、溶剂合物，其中R和R'的含义如本文所定义。本发明还涉及制备所述化合物的方法，含有它们的药物组合物以及它们在HCV治疗中的使用，单独或与其他HCV抑制剂结合使用。
• Di Bella; Monzani; Rinaldi, Farmaco, Edizione Scientifica, 1975, vol. 30, # 1, p. 47 - 57
  作者：Di Bella、Monzani、Rinaldi、Pecorari

  DOI：——

  日期：——
• ANILINO-PYRAZOLE DERIVATIVES, COMPOSITIONS AND METHODS THEREOF
  申请人：[en]ENSEM THERAPEUTICS, INC.

  公开号：WO2023244710A1

  公开（公告）日：2023-12-21

  The invention provides novel anilino-pyrazole derivatives as a cyclin-dependent kinase 2 (CDK2) inhibitors. The invention also provides pharmaceutical compositions comprising the compounds and methods thereof for treating various conditions, diseases and disorders associated with or related to CDK2 activities, or associated with abnormal cell growth, such as tumor growth and cancer.