5-Fluoro-2-(4-isopropylpiperazin-1-yl)pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-Fluoro-2-(4-isopropylpiperazin-1-yl)pyrimidine
• 英文别名: 5-fluoro-2-(4-propan-2-ylpiperazin-1-yl)pyrimidine
• 化学式: C₁₁H₁₇FN₄
• 分子量: 224.28
• InChiKey: YKDMTBCPBDXAHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
  申请人：ALI Amjad

  公开号：US20160194330A1

  公开（公告）日：2016-07-07

  Disclosed are compounds of Formula A: (structurally represented) where “RG1”, “RG2a”, “RG4”, “RG5”, “MG1”, “n” and “m” are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.

  本发明公开了A式化合物，其中“RG1”、“RG2a”、“RG4”、“RG5”、“MG1”、“n”和“m”在此被定义，这些化合物是A2A受体拮抗剂。本发明还公开了上述化合物作为A2A受体拮抗剂在潜在的涉及A2A受体的神经系统疾病的治疗或预防中的用途。本发明还公开了包含这些化合物的制药组合物以及这些制药组合物的用途。
• Inhibition of BMP Signaling Compounds, Compositions and Uses Thereof
  申请人：Vanderbilt University

  公开号：US20190218214A1

  公开（公告）日：2019-07-18

  Provided herein are substituted imidazo[1,2-a]pyridines useful as inhibitors of BMP signaling. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted imidazo [1,2-a] pyridines.
• US9676780B2
  申请人：——

  公开号：US9676780B2

  公开（公告）日：2017-06-13