(2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(4-cyclopentylpiperazine-1-yl-sulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(4-cyclopentylpiperazine-1-yl-sulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine
• 英文别名: (2R,3S,5R)-5-[2-(4-cyclopentylpiperazin-1-yl)sulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-2-(2,5-difluorophenyl)oxan-3-amine
• 化学式: C₂₅H₃₄F₂N₆O₃S
• 分子量: 536.646
• InChiKey: DOJIBIUTARTVBP-JHMXWDHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• AMINOTETRAHYDROPYRAN DERIVATIVE USED AS DIPEPTIDYL PEPTIDASEIV INHIBITOR
  申请人：FUJIAN BORO MEDICAL CO., LTD.

  公开号：US20170217964A1

  公开（公告）日：2017-08-03

  Provided is an Aminotetrahydropyran derivative represented by general formula (I), a preparation method for the derivative, a pharmaceutical composition containing the derivative, and the use of the derivative to prepare a therapeutic agent, especially a dipeptidyl peptidase-IV inhibitor.