4-ethyl-N,N-dimethylpiperazine-1-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-ethyl-N,N-dimethylpiperazine-1-sulfonamide
• 化学式: C₈H₁₉N₃O₂S
• 分子量: 221.32
• InChiKey: ADBMBEPADCFKKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Carbamate compounds as 5-HT4 receptor agonists
  申请人：Long D. Daniel

  公开号：US20080090811A1

  公开（公告）日：2008-04-17

  The invention provides novel benzoimidazolone-carboxamide-derived carbamate 5-HT 4 receptor agonist compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , a, and b are defined in the disclosure. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT 4 receptor activity, and processes and intermediates useful for preparing such compounds.

  本发明提供了一种新颖的苯并咪唑酮-羧酰胺衍生的碳酸酯5-HT4受体激动剂化合物，其化学式为(I)，其中R1、R2、R3、R4、a和b在本申请中有定义。本发明还提供了包含这些化合物的制药组合物，使用这些化合物治疗与5-HT4受体活性相关的疾病的方法，以及用于制备这些化合物的过程和中间体。
• PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE
  申请人：Bayliss Tracy

  公开号：US20080242665A1

  公开（公告）日：2008-10-02

  Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R 3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

  化学式Ia-d的化合物，其中X为S或O，mor为吗啡啶基团，R3为单环杂芳基团，包括立体异构体、几何异构体、互变异构体、溶剂化物、代谢物和药学上可接受的盐，可用于调节脂质激酶包括PI3K的活性，并用于治疗由脂质激酶介导的癌症等疾病。本文公开了使用化合物Ia-d的方法，用于哺乳动物细胞中体外、体内诊断、预防或治疗这种疾病或相关病理条件。
• CANNABINOID RECEPTOR LIGANDS AND USES THEREOF
  申请人：Griffith A. David

  公开号：US20070275964A1

  公开（公告）日：2007-11-29

  Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein.

  本文描述了化学式为(I)的化合物，它们作为大麻素受体配体并在动物中治疗与大麻素受体介导相关的疾病中的用途。
• TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
  申请人：Tao Chunlin

  公开号：US20080176853A1

  公开（公告）日：2008-07-24

  The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.

  本发明提供了三嗪衍生物及其在多种疾病和情况下调节蛋白激酶活性的用途。
• US7851467B2
  申请人：——

  公开号：US7851467B2

  公开（公告）日：2010-12-14