This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperazine (or similar) structure which function as antagonists of androgen receptor activity, and their use as therapeutics for the treatment of cancer (e.g., castration-resistant prostate cancer) and other conditions characterized with androgen receptor activity and/or androgen receptor expression.
这项发明属于药物
化学领域。具体地说,该发明涉及一类新型小分子,其具有
哌嗪(或类似)结构,能够作为雄激素受体活性的拮抗剂,并且它们被用作治疗癌症(例如去势抵抗性前列腺癌)和其他与雄激素受体活性和/或雄激素受体表达相关的疾病的治疗药物。