ethyl 1-(p-tolyl)piperidine-3-carboxylate | 1220529-78-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: ethyl 1-(p-tolyl)piperidine-3-carboxylate
• 英文别名: Ethyl 1-(4-methylphenyl)piperidine-3-carboxylate
• CAS: 1220529-78-1
• 化学式: C₁₅H₂₁NO₂
• 分子量: 247.337
• InChiKey: KYRJZIPLNICEKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对甲苯基溴化镁 、 ethyl 1-chloropiperidine-3-carboxylate 在 四甲基乙二胺 作用下， 以 四氢呋喃 为溶剂， 以89%的产率得到ethyl 1-(p-tolyl)piperidine-3-carboxylate
  参考文献：
  名称：

  Transition-Metal-Free Electrophilic Amination between Aryl Grignard Reagents and N-Chloroamines

  摘要：

  In the presence of N,N,N,N-tetramethylethylenediamine (TMEDA) as an additive, easily prepared and handled N-chloroamines react with aryl Grignard reagents to give a variety of arylamines in good to excellent yields. Functional groups such as ester and nitrile are compatible under the reaction conditions.

  DOI：

  10.1021/ol100235b

文献信息

• Transition-Metal-Free Electrophilic Amination between Aryl Grignard Reagents and <i>N</i>-Chloroamines
  作者：Takuji Hatakeyama、Yuya Yoshimoto、Sujit K. Ghorai、Masaharu Nakamura

  DOI：10.1021/ol100235b

  日期：2010.4.2

  In the presence of N,N,N,N-tetramethylethylenediamine (TMEDA) as an additive, easily prepared and handled N-chloroamines react with aryl Grignard reagents to give a variety of arylamines in good to excellent yields. Functional groups such as ester and nitrile are compatible under the reaction conditions.