5-[(3aR,4R,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: 5-[(3aR,4R,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid
• 化学式: C₁₀H₁₆N₂O₃S
• 分子量: 244.31
• InChiKey: YBJHBAHKTGYVGT-LKEWCRSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Techniques for enhancing the selectivity and efficacy of antimicrobial and anticancer polymer agents
  申请人：International Business Machines Corporation

  公开号：US11167036B2

  公开（公告）日：2021-11-09

  The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.

  本公开的主题涉及提高治疗用聚合物对多种病原体和癌细胞系的选择性和疗效的技术。根据一个实施方案，提供了一种方法，该方法包括基于多种治疗单体的聚合形成治疗聚合物，其中治疗聚合物提供治疗功能。该方法进一步包括将生物素附着到治疗用聚合物上，形成生物素官能化的治疗用聚合物，其中生物素官能化的治疗用聚合物相对于治疗用聚合物具有更大的治疗功效。
• TECHNIQUES FOR ENHANCING THE SELECTIVITY AND EFFICACY OF ANTIMICROBIAL AND ANTICANCER POLYMER AGENTS
  申请人：International Business Machines Corporation

  公开号：US20200164080A1

  公开（公告）日：2020-05-28

  The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.