8-叠氮基腺苷基3':5'-环状单磷酸酯 | 31966-52-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 中文名称: 8-叠氮基腺苷基3':5'-环状单磷酸酯
• 中文别名: 8-叠氮基腺苷-3',5'-环单磷酸酯；8-叠氮基腺苷基 3':5'-环状单磷酸酯
• 英文名称: 8-N3-cAMP
• 英文别名: (4aR,6R,7R,7aS)-6-(6-amino-8-azidopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
• CAS: 31966-52-6
• 化学式: C10H11N8O6P
• 分子量: 370.22
• InChiKey: KTMLKBFMGWQTEK-UUOKFMHZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  169
• 氢给体数：
  3
• 氢受体数：
  12

安全信息

• WGK Germany：
  3
• 海关编码：
  29389090

文献信息

• [EN] METHODS FOR PREDICTING, TREATING AND MODELLING HORMONE RESISTANCE<br/>[FR] PROCÉDÉS DE PRÉVISION, DE TRAITEMENT ET DE MODÉLISATION DE LA RÉSISTANCE AUX HORMONES
  申请人：INST NAT SANTE RECH MED

  公开号：WO2012168399A1

  公开（公告）日：2012-12-13

  The present invention provides novel mutations in the gene encoding for the regulatory subunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A) that are responsible for hormone resistance. Accordingly, the present invention relates to methods for predicting, treating and modelling hormone resistance. In particular, the present invention relates to a method for predicting whether a subject is at risk for having or developing a hormone resistance comprising the step consisting of detecting in a sample a mutation in PRKAR1A gene wherein the presence of said mutation is indicative of a risk of having or developing a hormone resistance.