N-Palmitoylsphingosinphosphorylcholin | 536-14-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: N-Palmitoylsphingosinphosphorylcholin
• 英文别名: N-Palmitoyldihydrosphingosinphosphorylcholin；Sphingomyelin d18:1-C16:0；[(E)-2-(hexadecanoylamino)-3-hydroxyoctadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 536-14-1；4846-15-5；6254-89-3；13053-57-1
• 化学式: C₃₉H₇₉N₂O₆P
• 分子量: 703.04
• InChiKey: RWKUXQNLWDTSLO-NHQGMKOOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.3
• 重原子数：
  48
• 可旋转键数：
  36
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• SPHINGOLIPIDS IN TREATMENT AND PREVENTION OF HEPATIC STEATOSIS
  申请人：Nederlandse Organisatie voor Toegepast -Natuurwetenschappelijk Onderzoek TNO

  公开号：EP1830829B1

  公开（公告）日：2012-01-04
• Sphingolipids in Treatment and Prevention of Steatosis and of Steatosis or of Hepatotoxicity and its Sequelae
  申请人：Nieuwenhuizen Willem Ferdinand

  公开号：US20080182902A1

  公开（公告）日：2008-07-31

  The present invention relates to the use of sphingolipids for the preparation of a food item, a food supplement and/or a medicament for the prevention and/or treatment of hepatotoxic effects such as hepatic steatosis, fibrosis and/or cirrhosis. In particular, the invention relates to the use of a sphingolipid with the general formula (I): wherein Z is R3 or —CH(OH)—R3; A is sulphate, isulphonate, phosphate, phosphonate or —C(O)O—; R1 is H, hydroxyl, alditol, glycosyl, an alcohol, C1-C6 alkyl or amino acid; R2 is H or unsaturated or saturated (C1-C30) alkyl chain; R3 is unsaturated or saturated (C1-C30) alkyl chain; Q1 is a primary amine group (—NH2), secondary amine group (—NH—) or an amide group (—NH—CO—); and t is 0 or 1, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the prevention and/or treatment of hepatotoxic effects such as hepatic steatosis, fibrosis and/or cirrhosis.
• US7906488B2
  申请人：——

  公开号：US7906488B2

  公开（公告）日：2011-03-15