3-methyl-piperidine-2-thione | 166535-87-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-methyl-piperidine-2-thione
• 英文别名: 3-Methylpiperidine-2-thione
• CAS: 166535-87-1
• 化学式: C₆H₁₁NS
• mdl: MFCD19220352
• 分子量: 129.226
• InChiKey: VAPBEZOZQSOAFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  44.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-methyl-piperidine-2-thione 在 锌 作用下， 以 氘代氯仿 为溶剂， 反应 16.0h， 生成 9-methyl-3,4,7,8-tetrahydro-2H,6H-pyrido<2,1-b><1,3>thiazine-2,4-dione
  参考文献：
  名称：

  8H-Anhydro-4-hydroxy-2-oxo-1,3-thiazinium Hydroxides as Mesoionic 1,4-Dipoles

  摘要：

  The previously unknown 8H-anhydro-4-hydroxy-2-oxo-1,3-thiazinium hydroxides (1) were prepared and their 1,4-dipolar cycloaddition behavior was examined. In most cases, elimination of the proton in the 8-position of the mesoionic ring was observed to occur unless extremely reactive dipolarophiles were used. The S,N-ketene acetals were converted to the corresponding alpha-diazo ketones for further study.

  DOI：

  10.3987/com-93-s(b)16-1
• 作为产物：
  描述：

  3-甲基哌啶-2-酮 在 劳森试剂 作用下， 以 四氢呋喃 为溶剂， 以44 %的产率得到3-methyl-piperidine-2-thione
  参考文献：
  名称：

  [EN] NOVEL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE SULFONAMIDE DERIVATIVES
  [FR] NOUVEAUX DÉRIVÉS D'IMIDAZOPYRIDINE ET DE PYRAZOLOPYRIDINE SULFONAMIDE

  摘要：

  The invention relates to novel compounds having the general formula I wherein R1, R2, X1, X2,X3and W are as described herein, composition including the compounds and methods of using the compounds.

  公开号：

  WO2024017857A1

文献信息

• AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS
  申请人：G.D. SEARLE & CO.

  公开号：EP0724570A1

  公开（公告）日：1996-08-07
• [EN] NOVEL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE SULFONAMIDE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS D'IMIDAZOPYRIDINE ET DE PYRAZOLOPYRIDINE SULFONAMIDE
  申请人：[en]F. HOFFMANN-LA ROCHE AG

  公开号：WO2024017857A1

  公开（公告）日：2024-01-25

  The invention relates to novel compounds having the general formula I wherein R1, R2, X1, X2,X3and W are as described herein, composition including the compounds and methods of using the compounds.
• 8H-Anhydro-4-hydroxy-2-oxo-1,3-thiazinium Hydroxides as Mesoionic 1,4-Dipoles
  作者：Albert Padwa、Steven J. Coats、Lazaros Hadjarapoglou

  DOI：10.3987/com-93-s(b)16

  日期：——

  The previously unknown 8H-anhydro-4-hydroxy-2-oxo-1,3-thiazinium hydroxides (1) were prepared and their 1,4-dipolar cycloaddition behavior was examined. In most cases, elimination of the proton in the 8-position of the mesoionic ring was observed to occur unless extremely reactive dipolarophiles were used. The S,N-ketene acetals were converted to the corresponding alpha-diazo ketones for further study.