4-(4-Amino-[1,3,5]triazin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester | 212264-36-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-Amino-[1,3,5]triazin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
• 英文别名: Tert-butyl 4-(4-amino-1,3,5-triazin-2-yl)piperazine-1-carboxylate
• CAS: 212264-36-3
• 化学式: C₁₂H₂₀N₆O₂
• 分子量: 280.33
• InChiKey: CSEMJZHMXJJPKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  97.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-Hexylsulfanyl-1,3,5-triazin-2-amine 、 N-Boc-哌嗪 以 1,4-二氧六环 为溶剂， 以94.5%的产率得到4-(4-Amino-[1,3,5]triazin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  A facile preparation of a combinatorial library of 2,6-disubstituted triazines

  摘要：

  Thiouronium salts of type 3 as dinucleophiles are excellent precursors for the synthesis of various heterocycles in combination through cyclization with a large variety of electrophiles. Using this strategy, 2,6-disubstituted-[l,3,5] triazines of types 4 and 6 have been prepared in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01164-2

文献信息

• A facile preparation of a combinatorial library of 2,6-disubstituted triazines
  作者：T. Masquelin、Y. Delgado、V. Baumlé

  DOI：10.1016/s0040-4039(98)01164-2

  日期：1998.8

  Thiouronium salts of type 3 as dinucleophiles are excellent precursors for the synthesis of various heterocycles in combination through cyclization with a large variety of electrophiles. Using this strategy, 2,6-disubstituted-[l,3,5] triazines of types 4 and 6 have been prepared in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.