4-Ethylsulfonyl-1,1-dimethylpiperazin-1-ium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-Ethylsulfonyl-1,1-dimethylpiperazin-1-ium
• 化学式: C8H19N2O2S+
• 分子量: 207.32
• InChiKey: ARVBLGVZMOYDHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER
  申请人：Han Gyoon Hee

  公开号：US20100144708A1

  公开（公告）日：2010-06-10

  The present invention relates to new heterocyclic compounds containing nitrogen atoms or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same for treatment of cancer. The compounds according to the present invention induce DNA damage due to reactive oxygen species to activate c-abl and p53, induce RhoB to generate apoptosis, and induce cell death by down-regulating Bcl2 involved in cell survival, which is generated by dysregulated signals via the mitochondria pathway, thereby inhibiting tumor cell growth and inducing apoptosis. Accordingly, the composition according to the present invention can be used to treat cancer.

  本发明涉及含有氮原子或其药用可接受盐的新杂环化合物，其制备方法以及包含相同的用于治疗癌症的药物组合物。根据本发明的化合物通过氧化性氧自由基引起DNA损伤，激活c-abl和p53，诱导RhoB产生凋亡，并通过下调参与细胞存活的Bcl2诱导细胞死亡，该Bcl2是通过线粒体途径的信号失调产生的，从而抑制肿瘤细胞生长并诱导凋亡。因此，根据本发明的组合物可用于治疗癌症。