3-[(4-Fluorophenyl)methylidene]thiochromen-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 英文名称: 3-[(4-Fluorophenyl)methylidene]thiochromen-4-one
• 化学式: C₁₆H₁₁FOS
• 分子量: 270.327
• InChiKey: GZSVOTCYCWLNRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,4-二硫-2,5-二醇 、 3-[(4-Fluorophenyl)methylidene]thiochromen-4-one 在 C₂₉H₂₉F₆N₂O₂⁽¹⁺⁾*Br^(1-) 作用下， 以 氯仿 为溶剂， 反应 48.0h， 以69%的产率得到
  参考文献：
  名称：

  Construction of polyheterocyclic spirotetrahydrothiophene derivatives via sulfa-Michael/aldol cascade reaction

  摘要：

  A series of polyheterocyclic spirotetrahydrothiophene derivatives were obtained in moderate to excellent yields via a catalyst-free sulfa-Michael/aldol cascade reaction of chalcones 1 and commercially available 1,4-dithiane-2,5-diol 2 under mild conditions. We also present the first asymmetric sulfa-Michael/aldol cascade reaction of chalcones 1 and commercially available 1,4-dithiane-2,5-diol 2 with moderate to good enantioselectivities catalyzed by readily available chiral phase-transfer catalysts (PTCs). (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.09.101

文献信息

• One-Pot Access to a Library of Dispiro Oxindole-pyrrolidine/pyrrolothiazole-thiochromane Hybrids via Three-Component 1,3-Dipolar Cycloaddition Reactions
  作者：Gandhi Uma Rani、Sundaravel Vivek Kumar、Chelliah Bharkavi、J. Carlos Menéndez、Subbu Perumal

  DOI：10.1021/acscombsci.6b00011

  日期：2016.6.13

  A library of novel dispiro compounds containing oxindole pyrrolidine/oxindolopyrrolothiazole-thiochroman-4-one hybrid frameworks has been synthesized in a fully regio- and stereoselective fashion by the three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the condensation of isatins and secondary amino acids (sarcosine/l-thioproline) with 3-arylidenethiochroman-4-ones

  通过缩合反应中原位生成的三组分1,3-偶极环加成甲硫氨酸以完全区域选择性和立体选择性的方式合成了一个含有二恶唑吡咯烷/恶臭吡咯并噻唑-thiochroman-4-one杂合骨架的新型双螺化合物3-亚芳基亚硫氰酸盐-4-酮对靛红和仲氨基酸（肌氨酸/ 1-硫代脯氨酸）的影响。这个简单的实验方案可在一次操作中提供结构复杂的，生物学上相关的杂环化合物的良好收率。