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热门化合物HOT

喹啉
水杨醛
二溴甲烷
谷胱甘肽
L-乳酸
苯巴比妥
辣椒碱
非那明
百草枯
联苯烯

13-Chloro-4-[2-(dimethylamino)ethyl-methylamino]-5,11,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaene-8,9-dione | 1454712-41-4

分子结构分类

有机化合物 - 有机杂环化合物 - 咪唑并[1，2-a]吡啶

中文名称

——

中文别名

——

英文名称

13-Chloro-4-[2-(dimethylamino)ethyl-methylamino]-5,11,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaene-8,9-dione

英文别名

13-chloro-4-[2-(dimethylamino)ethyl-methylamino]-5,11,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaene-8,9-dione

13-Chloro-4-[2-(dimethylamino)ethyl-methylamino]-5,11,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaene-8,9-dione化学式

CAS

1454712-41-4

化学式

C₁₉H₁₈ClN₅O₂

mdl

——

分子量

383.837

InChiKey

JMCBGJZFJJSNMW-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

2.9
重原子数：

27
可旋转键数：

4
环数：

4.0
sp3杂化的碳原子比例：

0.26
拓扑面积：

70.8
氢给体数：

0
氢受体数：

6

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	13-Chloro-5,11,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2(7),3,5,12,14,16-heptaene-8,9-dione	1454712-35-6	C₁₄H₆ClN₃O₂	283.674

反应信息

作为产物：

描述：

6,7-dichloroisoquinoline-5,8-dione 在 potassium carbonate 作用下，以四氢呋喃、乙醇为溶剂，反应 5.0h，生成 13-Chloro-4-[2-(dimethylamino)ethyl-methylamino]-5,11,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaene-8,9-dione

参考文献：

名称：

Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives

摘要：

A new series of substituted tri-/tetraazabenzo[3,2-alpha] fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines. (C) 2013 Elsevier Ltd. All rights reserved.

DOI：

10.1016/j.bmcl.2013.08.021

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文献信息

Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives

作者：Theerachart Leepasert、Manochehr Shahabi、Karem Shanab、Eva Schirmer、Wolfgang Holzer、Helmut Spreitzer、Babette Aicher、Gilbert Müller、Eckhard Günther

DOI：10.1016/j.bmcl.2013.08.021

日期：2013.10

A new series of substituted tri-/tetraazabenzo[3,2-alpha] fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines. (C) 2013 Elsevier Ltd. All rights reserved.

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