[Ru(η6-4-phenyl-2-butanol)(1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane)Cl2] | 876728-15-3

• 英文名称: [Ru(η6-4-phenyl-2-butanol)(1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane)Cl2]
• CAS: 876728-15-3
• 化学式: C₁₆H₂₆Cl₂N₃OPRu
• 分子量: 479.352
• InChiKey: JVWPKWMCGTZTTA-RASHCQHBSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  氟硼酸铵 、 [Ru(η6-4-phenyl-2-butanol)(1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane)Cl2] 、 三苯基膦 以 甲醇 为溶剂， 以91%的产率得到[Ru(η6-4-phenyl-2-butanol)(1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane)Cl(triphenylphosphine)]BF4
  参考文献：
  名称：

  Use of Perfluorinated Phosphines to Provide Thermomorphic Anticancer Complexes for Heat-Based Tumor Targeting

  摘要：

  A series of compounds of general formula [Ru(eta(6)-arene)(pta)(PR3)Cl]BF4 (arene = p-cymene or 4-phenyl-2-butanol; pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane, PR3 = PPh2(p-C6H4C2H4C8F17), PPh(p-C6H4C2H4C8F17)(2), P(p-C6H4C2H4C6F13)(3), PPh3 or P(p-C6H4F)(3)) have been prepared and characterized by spectroscopic methods. The structure of [Ru(eta(6)-p-cymene)(pta)Cl(P(p-C6H4F)(3))]BF4 has also been established in the solid state by X-ray crystallography. The cytotoxicities of the compounds were determined in the A2780 and A2780 cisplatin-resistant cell lines revealing that the fluorinated phosphines significantly increase antiproliferative activity relative to their bis-chloride precursors. Two of the complexes were found to be thermoresponsive, that is, showing poor water solubility at 37 degrees C and good solubility at 42 degrees C, the temperature of a heated tumor, providing a method of tumor targeting. Incubation at 42 degrees C for 2 h resulted in improved cytotoxicities for two of the complexes.

  DOI：

  10.1021/ic9020433