4-(5-Oxohexyl)-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: 4-(5-Oxohexyl)-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-2-one
• 化学式: C₁₁H₁₈N₂O₂S
• 分子量: 242.34
• InChiKey: YPKZJRGKHXINPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] SYNTHETIC PENTASACCHARIDES HAVING SHORT HALF-LIFE AND HIGH ACTIVITY<br/>[FR] PENTASACCHARIDES SYNTHÉTIQUES AYANT UNE DEMI-VIE COURTE ET UNE ACTIVITÉ ÉLEVÉE
  申请人：ENDOTIS PHARMA

  公开号：WO2012172104A1

  公开（公告）日：2012-12-20

  The invention concerns a pentasaccharide compound of formula (I) and the salts thereof. The invention also concerns a pharmaceutical composition comprising the synthetic pentasaccharide compound of formula (I) and its salts. The invention further concerns these compounds for use as a medicament, and in particular intended to treat blood clotting disorders, to prevent ischaemia reperfusion injury associated with solid organ transplantation, or to reduce the risk of blood clotting in an extracorporeal blood circuit during cardiac surgery, extracorporeal membrane oxygenation, or during circulatory assistance such as artificial heart.

  这项发明涉及一种化学式(I)及其盐的五糖化合物。该发明还涉及一种包括合成五糖化合物及其盐的药物组合物。此外，该发明还涉及这些化合物作为药物的用途，特别是用于治疗血液凝块疾病，预防固体器官移植相关的缺血再灌注损伤，或在心脏手术、体外膜肺氧合或人工心脏等循环辅助过程中减少体外循环血路中的血液凝块风险。
• [EN] QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION<br/>[FR] AMPLIFICATION DU SIGNAL D'ANALOGUES DE QUINONEMÉTHIDES
  申请人：VENTANA MED SYST INC

  公开号：WO2015124703A1

  公开（公告）日：2015-08-27

  Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

  本文披露了一种新型的醌甲烯类似物前体，以及使用该前体的方法和套件的实施例，用于检测生物样本中的一个或多个靶标。检测方法包括将样本与检测探针接触，然后将样本与包含酶的标记共轭物接触。酶与包含可检测标记的醌甲烯类似物前体相互作用，形成具有可检测标记的反应性醌甲烯类似物，该类似物与生物样本中的靶标近距离或直接结合。然后检测可检测标记。在某些实施例中，通过多个醌甲烯类似物前体与不同酶相互作用，无需酶去活化步骤即可检测多个靶标。
• [EN] EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS<br/>[FR] INHIBITEURS D'EPHA4 EN TANT QU'AGENTS NEUROPROTECTEURS
  申请人：UNIV HONG KONG SCIENCE & TECHN

  公开号：WO2015007222A1

  公开（公告）日：2015-01-22

  Provided is the discovery of the role of EphA4 signaling in neurodegenerative disorders involving β-amyloid induced neurotoxicity such as Alzheimer's Disease. New therapeutic methods, therapeutic agents, and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling.

  提供了EphA4信号在涉及β-淀粉样蛋白诱导的神经毒性等神经退行性疾病中的作用发现，如阿尔茨海默病。提供了用于治疗由过度活化的EphA4信号引起或加重的疾病的新疗法、治疗剂和工具。还提供了用于识别额外化合物作为治疗剂，对治疗涉及过度活跃的EphA4信号的条件有用的方法。
• USE OF ASCORBIC ACID DERIVATIVES FOR THE FUNCTIONALIZATION OF MATRICES
  申请人：Rudolph Thomas

  公开号：US20100167936A1

  公开（公告）日：2010-07-01

  The invention relates to the use of at least one ascorbic acid derivative for the functionalisation of matrices, and to specific ascorbic acid derivatives and processes for the preparation thereof.

  本发明涉及至少一种抗坏血酸衍生物的使用，用于基质的功能化，以及特定的抗坏血酸衍生物和其制备方法。
• Guanidinium delivery carriers
  申请人：Zhao Gang

  公开号：US20070078094A1

  公开（公告）日：2007-04-05

  Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.

  本文披露了含有胍基团的跨膜转运体化合物。本文还披露了使用跨膜转运体化合物将生物活性基团跨越生物膜的方法。特别地，本发明提供了一种将生物活性基团传递到内皮组织等生物膜的方法。