ethyl 1-benzyl-3-ethylpiperidine-Δ^4,α-acetate | 113386-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: ethyl 1-benzyl-3-ethylpiperidine-Δ^4,α-acetate
• 英文别名: ethyl (2Z)-2-(1-benzyl-3-ethylpiperidin-4-ylidene)acetate
• CAS: 113386-01-9
• 化学式: C₁₈H₂₅NO₂
• 分子量: 287.402
• InChiKey: WCOBHKGWWVVBHM-ATVHPVEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-苄基-3-甲氧基羰酰-4-哌啶酮 在 硫酸 、 sodium hydride 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 14.17h， 生成 ethyl 1-benzyl-3-ethylpiperidine-Δ^4,α-acetate
  参考文献：
  名称：

  Bonjoch, Josep; Linares, Ana; Guardia, Manel, Heterocycles, 1987, vol. 26, # 8, p. 2165 - 2174

  摘要：

  DOI：

文献信息

• New N-(benzhydryloxyalkyl)-4-(carboxy/carbamoylmethyl) piperidine derivatives with antidepressant activity
  作者：Y El Ahmad、P Maillet、E Laurent、A Talab、JF Teste、MJ Cédat、PY Fiez-Vandal、R Dokhan、R Ollivier

  DOI：10.1016/s0223-5234(97)83972-4

  日期：1997.1

  Several benzhydryloxylalkylpiperidine derivatives were prepared with the aim of obtaining new antidepressant compounds. The influence of the length of the aliphatic chain and of aromatic and piperidine ring substitutions was studied. The pharmacological activity of compounds was investigated in vivo by means of a screening comprising four pharmacological tests: antagonism of reserpine and apomorphine hypothermia; increase of yohimbine induced mortality; and antagonism of immobility in tail suspension test. An in-depth pharmacological study was performed with the more active compounds and a binding study to serotonin (5-HT), norepinephrine (NE) and dopamine (DA) reuptake sites was performed for the preferred compounds. The most active compounds [+], [-]-cis-31, 32 and 46 exhibited an interesting psychopharmacological profile after intraperitoneal administration. This profile was confirmed by the oral route for 31 and 46. In vitro, these compounds showed a non-selective inhibition of DA, NE and 5-HT uptake.
• Bonjoch, Josep; Linares, Ana; Guardia, Manel, Heterocycles, 1987, vol. 26, # 8, p. 2165 - 2174
  作者：Bonjoch, Josep、Linares, Ana、Guardia, Manel、Bosch, Joan

  DOI：——

  日期：——