N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-3-trifluoromethyl-benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-3-trifluoromethyl-benzenesulfonamide
• 英文别名: N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide
• 化学式: C₂₂H₂₅F₃N₂O₂S
• 分子量: 438.5
• InChiKey: QQZWYKIWJVUXFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  49
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• 4-phenylsulfonamidopiperidines as calcium channel blockers
  申请人：Benjamin Elfrida R.

  公开号：US20090105249A1

  公开（公告）日：2009-04-23

  The invention relates to piperidinyl compounds of Formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R 1 -R 3 and Z are defined as set forth in the specification. The invention is also directed to an assay useful for identifying such compounds as N-type calcium channel modulators or blockers. The invention is also directed to the compounds of Formula (I) and compounds identified by the above assay, and the use of such compounds to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

  该发明涉及式(I)的哌啶基化合物：或其药用可接受的盐、前药或溶剂，其中R1-R3和Z如规范中所述。该发明还涉及一种用于识别此类化合物作为N-型钙通道调节剂或阻断剂的测定方法。该发明还涉及式(I)的化合物和通过上述测定方法鉴定的化合物，以及使用这些化合物来治疗、预防或改善对钙通道阻断作出反应的疾病，尤其是N-型钙通道。本发明的化合物特别适用于治疗疼痛。
• Benzenesulfonamide Compounds and Their Use as Blockers of Calcium Channels
  申请人：Chen Zhengming

  公开号：US20100022595A1

  公开（公告）日：2010-01-28

  The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 -R 3 , Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及公式（I）的哌啶基和六氢唑啉基化合物及其药学上可接受的盐，前药或溶剂，其中R1-R3，Z和q如规范中所述。本发明还针对使用公式（I）的化合物治疗、预防或改善对钙通道阻滞有响应的疾病，特别是N型钙通道。本发明的化合物特别适用于治疗疼痛。
• Benzenesulfonamide Compounds and the Use Thereof
  申请人：Matsumura Akira

  公开号：US20090306136A1

  公开（公告）日：2009-12-10

  The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 -R 3 , Z, p and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及式（I）的吡咯烷基，吡咯啉基，哌啶基和六氢氮杂环基化合物，以及其药学上可接受的盐，前药或溶剂化物，其中R1-R3，Z，p和q如规范所述。本发明还涉及使用式（I）的化合物治疗，预防或改善对钙通道阻滞有反应的疾病，特别是N型钙通道。本发明的化合物特别适用于治疗疼痛。
• 4-PHENYLSULFONAMIDOPIPERIDINES AS CALCIUM CHANNEL BLOCKERS
  申请人：EURO-CELTIQUE S.A.

  公开号：EP1814851B1

  公开（公告）日：2013-06-05
• US8791264B2
  申请人：——

  公开号：US8791264B2

  公开（公告）日：2014-07-29