N-(3-aminopropyl)-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: N-(3-aminopropyl)-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamide
• 化学式: C₁₃H₂₄N₄O₂S
• 分子量: 300.42
• InChiKey: LKPUEUXUOQHTRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• [EN] ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF<br/>[FR] DÉRIVÉS D'ANHYDRIDE ISATOÏQUE ET LEURS APPLICATIONS
  申请人：UNIV NORTH CAROLINA

  公开号：WO2015163952A1

  公开（公告）日：2015-10-29

  Isatoic anhydride derivatives having an N-substituent which includes a quaternary ammonium group are useful for labeling and/or functionalizing a target material and/or for coupling materials together. The isatoic anhydride derivatives of the present disclosure can be advantageously water soluble, easily prepared and purified. Isatoic anhydride derivatives useful in the present disclosure preferably have at least one chemically reactive group or at least one binding group or at least one detectable label. Anthranilate derivatives made from the isatoic anhydrides derivatives or otherwise and kits including the isatoic anhydride derivatives are also disclosed.

  异烟酰亚胺衍生物具有包括季铵基团的N-取代基，可用于标记和/或功能化目标材料和/或将材料耦合在一起。本公开的异烟酰亚胺衍生物可以具有优势的水溶性，易于制备和纯化。本公开中有用的异烟酰亚胺衍生物最好至少具有一个化学反应性基团或至少一个结合基团或至少一个可检测标记。从异烟酰亚胺衍生物制备的邻氨基苯甲酸酯衍生物或其他衍生物以及包括异烟酰亚胺衍生物的试剂盒也被公开。
• [EN] BIOMIMETIC NANOMATERIALS AND USES THEREOF<br/>[FR] NANOMATÉRIAUX BIOMIMÉTIQUES ET LEURS UTILISATIONS
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2019027999A1

  公开（公告）日：2019-02-07

  The present disclosure relates to biomimetic nanomaterials, compounds, compositions, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a nucleic acid).

  本公开涉及仿生纳米材料、化合物、组合物以及用于传递治疗、诊断或预防剂（例如核酸）的方法。
• Light-stimulated release of cargo from oligonucleotides
  申请人：Trustees of Boston University

  公开号：US10617759B2

  公开（公告）日：2020-04-14

  The invention provides oligonucleotide conjugates including a photolabile crosslinker attached to a cargo moiety, e.g., a therapeutic or diagnostic agent. The invention further provides reagents useful in the preparation of such conjugates and methods of their use.

  本发明提供了寡核苷酸共轭物，包括连接到货物分子（如治疗剂或诊断剂）上的光敏交联剂。本发明进一步提供了用于制备此类共轭物的试剂及其使用方法。
• ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF
  申请人：The University of North Carolina at Charlotte

  公开号：US20170035893A1

  公开（公告）日：2017-02-09

  Isatoic anhydride derivatives having an N-substituent which includes a quaternary ammonium group are useful for labeling and/or functionalizing a target material and/or for coupling materials together. The isatoic anhydride derivatives of the present disclosure can be advantageously water soluble, easily prepared and purified. Isatoic anhydride derivatives useful in the present disclosure preferably have at least one chemically reactive group or at least one binding group or at least one detectable label. Anthranilate derivatives made from the isatoic anhydrides derivatives or otherwise and kits including the isatoic anhydride derivatives are also disclosed.
• BIOMIMETIC NANOMATERIALS AND USES THEREOF
  申请人：Ohio State Innovation Foundation

  公开号：US20210069336A1

  公开（公告）日：2021-03-11

  The present disclosure relates to biomimetic nanomaterials, compounds, compositions, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a nucleic acid).