2-(phenylethynyl)dibenzofuran | 933883-60-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-(phenylethynyl)dibenzofuran
• 英文别名: 2-(2-Phenylethynyl)dibenzofuran；2-(2-phenylethynyl)dibenzofuran
• CAS: 933883-60-4
• 化学式: C₂₀H₁₂O
• 分子量: 268.315
• InChiKey: QOFLOARUXAWGER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-溴二苯并呋喃 、 苯乙炔 在 copper(l) iodide 、 四(三苯基膦)钯 、 三乙胺 作用下， 以 乙醇 、 水 为溶剂， 反应 24.0h， 以82%的产率得到2-(phenylethynyl)dibenzofuran
  参考文献：
  名称：

  Rhodium-Catalyzed Decarbonylative C–H Arylation of 2-Aryloxybenzoic Acids Leading to Dibenzofuran Derivatives

  摘要：

  Rhodium-catalyzed intramolecular C-H arylation of 2-aryloxybenzoic acids proceeded accompanied by decarbonylation to give dibenzofuran derivatives in high yields. The present reaction is widely applicable to substrates bearing various functionalities.

  DOI：

  10.1021/ol4010905

文献信息

• Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof
  申请人：Cocklin Simon

  公开号：US20130165489A1

  公开（公告）日：2013-06-27

  The present invention includes a method of inhibiting, suppressing or preventing a viral infection in a subject, comprising administering to the subject a pharmaceutical composition comprising one or more of the compounds useful within the invention.
• [EN] SMALL-MOLECULE MODULATORS OF HIV-1 CAPSID STABILITY AND METHODS THEREOF<br/>[FR] MODULATEURS À PETITE MOLÉCULE DE STABILITÉ DE CAPSIDE DE VIH-1 ET PROCÉDÉS POUR CEUX-CI
  申请人：PHILADELPHIA HEALTH & EDUCATIO

  公开号：WO2011139637A1

  公开（公告）日：2011-11-10

  The present invention includes a method of treating or preventing a viral infection in a subject, comprising the step of administering to the subject a pharmaceutical composition comprising one or more of the compounds useful within the invention.
• Rhodium-Catalyzed Decarbonylative C–H Arylation of 2-Aryloxybenzoic Acids Leading to Dibenzofuran Derivatives
  作者：Shinji Maetani、Takahide Fukuyama、Ilhyong Ryu

  DOI：10.1021/ol4010905

  日期：2013.6.7

  Rhodium-catalyzed intramolecular C-H arylation of 2-aryloxybenzoic acids proceeded accompanied by decarbonylation to give dibenzofuran derivatives in high yields. The present reaction is widely applicable to substrates bearing various functionalities.