α-Brom-p-benzoyloxypropiophenon | 35282-40-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: α-Brom-p-benzoyloxypropiophenon
• 英文别名: 1-(4-benzoyloxy-phenyl)-2-bromo-propan-1-one；1-(4-Benzoyloxy-phenyl)-2-brom-propan-1-on；1-[4-(benzoyloxy)phenyl]-2-bromo-1-propanone；4-(2-Bromopropanoyl)phenyl benzoate；[4-(2-bromopropanoyl)phenyl] benzoate
• CAS: 35282-40-7
• 化学式: C₁₆H₁₃BrO₃
• 分子量: 333.181
• InChiKey: RVZGNNYQEQMALE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-苯硫基丙-2-胺 、 α-Brom-p-benzoyloxypropiophenon 以 苯 为溶剂， 生成
  参考文献：
  名称：

  Andrisano,R.; Angeloni,A.S., Chimica Therapeutica, 1971, vol. 6, p. 474 - 478

  摘要：

  DOI：
• 作为产物：
  描述：

  4-propionylphenyl benzoate 在 三氯化铝 、 溴 、 calcium carbonate 作用下， 以 二氯甲烷 为溶剂， 生成 α-Brom-p-benzoyloxypropiophenon
  参考文献：
  名称：

  Andrisano,R.; Angeloni,A.S., Chimica Therapeutica, 1971, vol. 6, p. 474 - 478

  摘要：

  DOI：

文献信息

• Process for producing optically active beta-amino alcohol
  申请人：Nishiyama Akira

  公开号：US20050277791A1

  公开（公告）日：2005-12-15

  A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to yield a diastereomer mixture of an optically active α-substituted aminoketone. One of the diastereomers is isolated optionally after the diastereomers are converted to salts with an acid. The optically active α-substituted aminoketone or a salt thereof thus isolated was stereoselectively reduced to yield an optically active β-substituted amino alcohol. The optically active β-substituted amino alcohol is subjected to hydrogenolysis to produce an optically active β-amino alcohol or a salt thereof.

  提供了一种从廉价、易得的起始材料中轻松生产有用于制药中间体的光学活性β-氨基醇的方法。将易得的α-取代酮与光学活性胺反应，得到光学活性α-取代氨基酮的对映体混合物。在对映体混合物与酸转化为盐之后，可以选择性地分离其中一种对映体。分离出的光学活性α-取代氨基酮或其盐经立体选择性还原，得到光学活性β-取代氨基醇。将光学活性β-取代氨基醇进行氢解反应，得到光学活性β-氨基醇或其盐。
• Process for producing optically active β-amino alcohol
  申请人：Kaneka Corporation

  公开号：US07408084B2

  公开（公告）日：2008-08-05

  A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to yield a diastereomer mixture of an optically active α-substituted aminoketone. One of the diastereomers is isolated optionally after the diastereomers are converted to salts with an acid. The optically active α-substituted aminoketone or a salt thereof thus isolated was stereoselectively reduced to yield an optically active β-substituted amino alcohol. The optically active β-substituted amino alcohol is subjected to hydrogenolysis to produce an optically active β-amino alcohol or a salt thereof.

  提供一种从廉价易得的起始物质中轻松生产有用于制药中间体的光学活性β-氨基醇的方法。将易得的α-取代酮与光学活性胺反应，得到光学活性α-取代氨基酮的对映体混合物。在将对映体转化成盐酸盐后，可以选择性地分离其中的一种对映体。随后，光学活性α-取代氨基酮或其盐被立体选择性还原，得到光学活性β-取代氨基醇。最后，对光学活性β-取代氨基醇进行氢解反应，得到光学活性β-氨基醇或其盐。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE s-AMINO ALCOHOL
  申请人：KANEKA CORPORATION

  公开号：EP1512677A1

  公开（公告）日：2005-03-09

  A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to yield a diastereomer mixture of an optically active α-substituted aminoketone. One of the diastereomers is isolated optionally after the diastereomers are converted to salts with an acid. The optically active α-substituted aminoketone or a salt thereof thus isolated was stereoselectively reduced to yield an optically active β-substituted amino alcohol. The optically active β-substituted amino alcohol is subjected to hydrogenolysis to produce an optically active β-amino alcohol or a salt thereof.

  本发明提供了一种利用廉价易得的起始原料轻松生产具有光学活性的 β-氨基醇作为药物中间体的工艺。现成的 α 取代酮与光学活性胺反应，生成光学活性 α 取代氨基酮的非对映异构体混合物。非对映异构体中的一种非对映异构体在与酸转化成盐后被分离出来。这样分离出的具有光学活性的 α-取代氨基酮或其盐经立体选择性还原后得到具有光学活性的 β-取代氨基醇。将光学活性 β-取代氨基醇进行氢解，生成光学活性 β-氨基醇或其盐。
• EP1512677
  申请人：——

  公开号：——

  公开（公告）日：——
• Torres; Amargos, Anales de la Real Sociedad Espanola de Fisica y Quimica, 1933, vol. 31, p. 37,42
  作者：Torres、Amargos

  DOI：——

  日期：——