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6-chloro-4-ethyl-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide | 792215-49-7

中文名称
——
中文别名
——
英文名称
6-chloro-4-ethyl-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide
英文别名
6-Chloro-4-ethylthieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide
6-chloro-4-ethyl-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide化学式
CAS
792215-49-7
化学式
C7H7ClN2O2S2
mdl
——
分子量
250.73
InChiKey
KNMLDOLSGAEOHW-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.9
  • 重原子数:
    14
  • 可旋转键数:
    1
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.29
  • 拓扑面积:
    86.4
  • 氢给体数:
    0
  • 氢受体数:
    4

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    6-chloro-4-ethyl-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide 在 sodium tetrahydroborate 作用下, 以 异丙醇 为溶剂, 反应 0.08h, 以45%的产率得到6-Chloro-4-ethyl-3,4-dihydro-2H-thieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide
    参考文献:
    名称:
    Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors
    摘要:
    On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the design of original isosteric 3,4-dihydro-2H-thieno-1,2,4-thiadiazine 1,1-dioxides. Owing to the sulfur position, three series of compounds were developed and their activity as AMPA potentiators was characterized. In each of the developed series, potent compounds were discovered. After screening the selected active compounds on a safety in vivo test, 6-chloro-4-ethyl-3,4-dihydro-2H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide (24) appeared as the most promising compound and was further evaluated. Its effects on long-term potentiation in vivo and on AMPA-mediated noradrenaline release were measured to predict its potential cognitive enhancing properties. Finally, an object recognition test performed in mice revealed that 24 was able to significantly enhance cognition, after oral administration, at doses as low as 0.3 mg/kg. This study validates the interest of the isosteric replacement of the benzene or pyridine nuclei by the thiophene nucleus in the ring-fused thiadiazine dioxides class of AMPA potentiators.
    DOI:
    10.1021/jm400676g
  • 作为产物:
    描述:
    溴乙烷6-chloro-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxidepotassium carbonate 作用下, 以 N,N-二甲基甲酰胺乙腈 为溶剂, 反应 7.0h, 以68%的产率得到6-chloro-4-ethyl-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide
    参考文献:
    名称:
    Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors
    摘要:
    On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the design of original isosteric 3,4-dihydro-2H-thieno-1,2,4-thiadiazine 1,1-dioxides. Owing to the sulfur position, three series of compounds were developed and their activity as AMPA potentiators was characterized. In each of the developed series, potent compounds were discovered. After screening the selected active compounds on a safety in vivo test, 6-chloro-4-ethyl-3,4-dihydro-2H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide (24) appeared as the most promising compound and was further evaluated. Its effects on long-term potentiation in vivo and on AMPA-mediated noradrenaline release were measured to predict its potential cognitive enhancing properties. Finally, an object recognition test performed in mice revealed that 24 was able to significantly enhance cognition, after oral administration, at doses as low as 0.3 mg/kg. This study validates the interest of the isosteric replacement of the benzene or pyridine nuclei by the thiophene nucleus in the ring-fused thiadiazine dioxides class of AMPA potentiators.
    DOI:
    10.1021/jm400676g
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文献信息

  • Thiadiazine derivatives and use thereof as positive ampa receptor modulators
    申请人:Francotte Pierre
    公开号:US20070004709A1
    公开(公告)日:2007-01-04
    Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond, R 1 represents hydrogen, linear or branched (C 1 -C 6 )alkyl optionally substituted by one or more groups selected from halogen or (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, R 2 represents hydrogen or linear or branched (C 1 -C 6 )alkyl group optionally substituted by one or more halogen, R 3 represents hydrogen or a group selected from linear or branched (C 1 -C 6 )alkyl, CONHR′ and SO 2 NHR′ wherein R′ represents linear or branched (C 1 -C 6 )alkyl, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same, which are useful as AMPA inhibitors.
    化合物的式子(I): 其中: A代表噻吩基、呋喃基、吡咯基、氧硫杂环基、噻唑基、异噻唑基、噁唑基或咪唑基; 代表单键或双键; R1代表氢、线性或支链(C1-C6)烷基,可选地被卤素或(C1-C6)烷氧基-(C1-C6)烷基中的一种或多种基团取代; R2代表氢或线性或支链(C1-C6)烷基,可选地被一种或多种卤素取代; R3代表氢或从线性或支链(C1-C6)烷基、CONHR′和SO2NHR′中选出的一种基团,其中R′代表线性或支链(C1-C6)烷基。这些化合物的对映体和二对映异构体,以及与药学上可接受的酸或碱形成的加合物都包括在内。含有这些化合物的药物,可用作AMPA抑制剂。
  • US7476668B2
    申请人:——
    公开号:US7476668B2
    公开(公告)日:2009-01-13
  • Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors
    作者:Pierre Francotte、Eric Goffin、Pierre Fraikin、E. Graindorge、Pierre Lestage、Laurence Danober、Sylvie Challal、Nathalie Rogez、Olivier Nosjean、Daniel-Henri Caignard、Bernard Pirotte、Pascal de Tullio
    DOI:10.1021/jm400676g
    日期:2013.10.24
    On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the design of original isosteric 3,4-dihydro-2H-thieno-1,2,4-thiadiazine 1,1-dioxides. Owing to the sulfur position, three series of compounds were developed and their activity as AMPA potentiators was characterized. In each of the developed series, potent compounds were discovered. After screening the selected active compounds on a safety in vivo test, 6-chloro-4-ethyl-3,4-dihydro-2H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide (24) appeared as the most promising compound and was further evaluated. Its effects on long-term potentiation in vivo and on AMPA-mediated noradrenaline release were measured to predict its potential cognitive enhancing properties. Finally, an object recognition test performed in mice revealed that 24 was able to significantly enhance cognition, after oral administration, at doses as low as 0.3 mg/kg. This study validates the interest of the isosteric replacement of the benzene or pyridine nuclei by the thiophene nucleus in the ring-fused thiadiazine dioxides class of AMPA potentiators.
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