N,N-二(1-甲基乙基)氨基亚膦酸 6-[[6-[二(4-甲氧基苯基)苯基甲氧基]己基]二硫基]己基 2-氰基乙基酯 | 148254-21-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 中文名称: N,N-二(1-甲基乙基)氨基亚膦酸 6-[[6-[二(4-甲氧基苯基)苯基甲氧基]己基]二硫基]己基 2-氰基乙基酯
• 中文别名: N,N-二(1-甲基乙基)氨基亚膦酸6-[[6-[二(4-甲氧基苯基)苯基甲氧基]己基]二硫基]己基2-氰基乙基酯
• 英文名称: Thiol-Modifier C6 S-S
• 英文别名: 3-[6-[6-[bis(4-methoxyphenyl)-phenylmethoxy]hexyldisulfanyl]hexoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
• CAS: 148254-21-1
• 化学式: C₄₂H₆₁N₂O₅PS₂
• 分子量: 769.062
• InChiKey: VEONRKLBSGQZRU-UHFFFAOYSA-N

物化性质

• 沸点：
  757.4±60.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  52
• 可旋转键数：
  28
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  9

安全信息

• WGK Germany：
  3
• 危险性防范说明：
  P261,P264,P270,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P330,P362,P403+P233,P501
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为产物：
  描述：

  6,6'-二硫烷二基二(1-己醇) 在 N-甲基吗啉 、 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 4.33h， 生成 N,N-二(1-甲基乙基)氨基亚膦酸 6-[[6-[二(4-甲氧基苯基)苯基甲氧基]己基]二硫基]己基 2-氰基乙基酯
  参考文献：
  名称：

  Complexation and conjugation approaches to evaluate siRNA delivery using cationic, hydrophobic and amphiphilic peptides

  摘要：

  在这项研究中，我们采用固相合成法制备了三种多肽，然后配制了多肽-siRNA复合物和多肽-siRNA共轭物。复合物和共轭物均无毒，无需任何转染剂即可将 siRNA 运送到细胞质中，并抑制基因表达。

  DOI：

  10.1039/c1ob06042b

文献信息

• Chemically-defined non-polymeric valency platform molecules and conjugates thereof
  申请人：Coutts M. Stephen

  公开号：US20070254851A1

  公开（公告）日：2007-11-01

  Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.

  化学定义的非聚合价平台分子和共轭物，包括化学定义的价平台分子和生物或化学分子，其中包括至少具有20个碱基对的多核苷酸双链，对人类狼疮抗dsDNA自身抗体具有显著的结合活性。
• CHEMICALLY-DEFINED NON-POLYMERIC VALENCY PLATFORM MOLECULES AND CONJUGATES THEREOF
  申请人：COUTTS Stephen M.

  公开号：US20080293660A1

  公开（公告）日：2008-11-27

  Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.

  化学定义的、非聚合物的价态平台分子和共轭物，包括化学定义的价态平台分子和生物或化学分子，其中包括至少具有20个碱基对的多核苷酸双链，对人类狼疮抗dsDNA自身抗体具有显著的结合活性。
• Chemically Ligated RNAs for CRISPR/Cas9-lgRNA Complexes as Antiviral Therapeutic Agents
  申请人：Zhong Minghong

  公开号：US20160215275A1

  公开（公告）日：2016-07-28

  Provided herein are chemically ligated guide RNA oligonucleotides (lgRNA) which comprise two functional RNA modules (crgRNA and tracrgRNA) joined by non-nucleotide chemical linkers (nNt-linker), their complexes with CRISPR-Cas9, preparation methods of Cas9-lgRNA complexes, and their uses for treatments of viral infections in humans. Also disclosed are processes and methods for preparation of these compounds.
• HIGH-SPEED PHOTO-CROSS-LINKING LINKER FOR MOLECULAR INTERACTION ANALYSIS AND IN VITRO SELECTION, AND IN VITRO SELECTION METHOD USING LINKER
  申请人：Saitama University

  公开号：US20180100146A1

  公开（公告）日：2018-04-12

  Provided is a linker for both screening assessment of the candidate clones without using enzymes, and to provide an in vitro selection method using thereof. Also, provided is a high-speed photo-crosslinking linker for molecular interaction analysis and in vitro selection comprising a backbone and a side chain. The backbone comprises a solid-phase binding site located at the 5′ terminus for forming a bond with a solid-phase; a solid-phase cleavage site for releasing the entire solid-phase at the site; a side chain linking site for linking a side chain; a high-speed photo-crosslinking site for linking the backbone to mRNA having a sequence complementary thereof via photo-cros slinking; and a reverse transcription initiation region located adjacent to the side chain linking site at the 3′ terminus of the backbone. The side chain comprises a fluorescent label, a protein binding site located at the free terminus thereof; and a binding site with the backbone.
• US7351855B2
  申请人：——

  公开号：US7351855B2

  公开（公告）日：2008-04-01