3-Cyclohexyl-6-chloro-7-sulfamoyl-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide | 1824-65-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 3-Cyclohexyl-6-chloro-7-sulfamoyl-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide
• 英文别名: 6-chloro-3-cyclohexyl-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
• CAS: 1824-65-3
• 化学式: C₁₃H₁₈ClN₃O₄S₂
• 分子量: 379.889
• InChiKey: HNDPIJYXKATYAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  环己烷基甲醛 生成 3-Cyclohexyl-6-chloro-7-sulfamoyl-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide
  参考文献：
  名称：

  Novel compounds and their use as positive AMPA receptor modulators

  摘要：

  该发明提供了一种新型化合物，其通式5的化合物如下所示：其中由虚线表示的键可以是单键、双键或不存在；如果键不存在，则氮原子用氢和R2取代；X代表SO2或C═O或CH2；Y代表—CH(R4)—、—N(R4)—或—N(R4)—CH2—、O；R2、R3、R4、R5、R6、R7和R8的含义如申请中所定义。这些化合物可用作AMPA受体的阳性调节剂。

  公开号：

  US20040043987A1

文献信息

• Compounds and their use as positive AMPA receptor modulators
  申请人：NeuroSearch A/S

  公开号：US07235548B2

  公开（公告）日：2007-06-26

  The invention provides novel compounds represented by the general formula compound represented by the formula: wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C═O or CH2; Y represents —CH(R4)—, —N(R4)— or —N(R4)—CH2—, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.

  本发明提供了由一般式化合物表示的新化合物，该一般式化合物由以下式子表示：其中，由断线表示的键可以是单键、双键或不存在；如果键不存在，则氮被氢和R2取代；X代表SO2、C═O或CH2；Y代表—CH(R4)—、—N(R4)—或—N(R4)—CH2—、O；而R2、R3、R4、R5、R6、R7和R8的含义如申请书中所定义。这些化合物可用作AMPA受体的正向调节剂。
• NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS
  申请人：NEUROSEARCH A/S

  公开号：EP1071426A2

  公开（公告）日：2001-01-31
• METHODS AND COMPOSITIONS FOR TREATING PATHOLOGIES ASSOCIATED WITH BDNF SIGNALING
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US20170209425A1

  公开（公告）日：2017-07-27

  A method of treating non-neurodegenerative pathologies associated with derangement in brain-derived neurotrophic factor signaling in the brain stem includes administering to the subject an amount of at least one ampakine effective to increase brain-derived neurotrophic factor nodose sensory neurons of the subject.
• US6943159B1
  申请人：——

  公开号：US6943159B1

  公开（公告）日：2005-09-13
• US7235548B2
  申请人：——

  公开号：US7235548B2

  公开（公告）日：2007-06-26